This study was undertaken to validate the use of microbial biotransformation systems for drug metabolism studies. Thymoxamine 1 was rapidly hydrolyzed to desacetylthymoxamine (DAT) 2 by numerous fungi. Other known animal metabolites, such as N-desmethyl-desacetylthymoxamine 3 and desacetylthymoxamine-O-sulfate 6, were produced from DAT by Mucor rouxii and Mortierella isabellina. DAT-N-oxide 5, ...

objective fungi produce many different carotenoids and some are attractive in medical and industrial sources. in this work the ability of mucor hiemalis (ptcc 5292) to produce carotenoids in media with different nitrogenous and carbon sources and incubation with white, yellow, blue and red lights (15w, 220v, e27) against dark-grown were studied. materials and method the microorganism cultivatio...

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This paper reports about design and development of a novel mobile electronic nose assembly, which is an inspection cum controlling system. It is used to detect and control the fungi growth. The Model is tested in North-Eastern (Shillong) Region of India. The diseases like Aspergillosis, mucor amphibiorum, penicillium marneffei and hypersensitivity pneumonic are caused due to long term exposure ...

Fungi are well known by their ability to excrete enzymes into the environment. Among them, representatives of Mucor Fresen. have important biotechnological potential and some of them produce industrial enzymes. This work studied amylase, lipase, polygalacturonase and protease production by fifty-six isolates of Mucor belonging to 11 different taxa, selected from herbivores dung using solid medi...

The structure of mucor pusillus pepsin (EC 3.4.23.6), the aspartic proteinase from Mucor pusillus, has been refined to a crystallographic R-factor of 16.2% at 2.0 A resolution. The positions of 2638 protein atoms, 221 solvent atoms and a sulphate ion have been determined with an estimated root-mean-square (r.m.s.) error of 0.15 to 0.20 A. In the final model, the r.m.s. deviation from ideality f...

The aim of this study was to isolate and identify airborne fungi from locations in Babol city, Babolkenar forest and a beach on the Caspian Sea (all in North part of Iran) in spring and summer. Of 126 samples collected, the most clinically important isolated fungi were Mucor spp. (18.6%) in the forest, Alternaria spp. (13.4%) at the beach; and Cladophialophora spp. (15.8%), Mucor spp. (11.7%) a...

Lipase of Mucor pusillus NRRL 2543 was recovered with ammonium sulfate precipitation, gel filtration on Sephadex G-75, and anion-exchange chromatography on diethylaminoethyl-Sephadex A-50. Maximal glycerol ester hydrolase (lipase) activity was observed at pH 5.0 to 5.5 and 50 C when trioctanoin and olive oil were used as substrates. The enzyme also showed esterase activity; it hydrolyzed, with ...