Multicomponent reactions (MCRs) are one of the most important processes for the preparation of highly functionalized organic compounds in modern synthetic chemistry. As shown in this review, they play an important role in organophosphorus chemistry where phosphorus reagents are used as substrates for the synthesis of a wide range of phosphorylated heterocycles. In this article, an overview abou...

In this work, the efficiency, generality and applicability of new Bronsted acidic ionic liquid (BAIL) 1-methyl-3-(2-(sulfooxy)ethyl)-1H-imidazol-3-ium chloride {[Msei]Cl} as heterogeneous and green catalyst for organic transformations are studied. Herein, the following one-pot multi-component reactions in the presence of [Msei]Cl are investigated: (i) the synthesis of quinoxaline derivatives fr...

Oxindole derivatives are known for their great interest in the field of Medicinal Chemistry, as they display vast biological activities. Recent efforts concerning preparation oxindole using isatin-based multicomponent reactions (MCRs) constitute a advance generating druglike libraries fast and with wide scaffold diversity. In this review, we address those recent developments, exploring syntheti...

Selenocysteine containing peptoids and peptide-peptoid conjugates were synthesized by combinatorial Ugi-MCRs (multicomponent reactions) in water: for the first time, an acetal (selenoacetal 2a) was used in Ugi-MCR to furnish selenocysteine peptoids in one step as model compounds for selenocysteine peptides and proteins.

in this work, the efficiency, generality and applicability of new bronsted acidic ionic liquid (bail) 1-methyl-3-(2-(sulfooxy)ethyl)-1h-imidazol-3-ium chloride {[msei]cl} as heterogeneous and green catalyst for organic transformations are studied. herein, the following one-pot multi-component reactions in the presence of [msei]cl are investigated: (i) the synthesis of quinoxaline derivatives fr...

We consider production technologies in which several parallel component processes are characterized by both component-specific and shared inputs outputs. The recently developed multicomponent variable constant returns-to-scale (MVRS MCRS) models of such based on the assumption that we have no information about actual allocation outputs to processes, is a common scenario many applications. MVRS ...

A water-accelerated multi-component synthesis of organic target molecules was used as a key method for the preparation of cyclopentadiene derivatives. The three-component condensation reactions of primary amines with alkyl propiolates in the presence of N-methylimidazole in water at room temperature were developed as efficient and clean green synthetic procedures for the high-yielding preparati...

Reinforcement Learning (RL) paradigm aims to develop algorithms that allow to train an agent to optimally achieve a goal with minimal feedback information about the desired behavior, which is not precisely specified. Scalar rewards are returned to the agent as response to its actions endorsing or opposing them. RL algorithms have been succesfully applied to robot control design. The extension o...