B. anthracis is a bioweapon of primary importance and its pathogenicity depends on its lethal and edema toxins, which belong to the A-B model of bacterial toxins, and on its capsule. These toxins are secreted early in the course of the anthrax disease and for this reason antibiotics must be administered early, in addition to other limitations. Antibodies (Abs) may however neutralize those toxin...

This paper presents a new Analysis-by-Synthesis (AbS) technique for joint optimization of the excitation and model parameters based on minimizing the closed loop synthesis error instead of the linear prediction error. By minimizing the synthesis error, the analysis and synthesis stages become more compatible. Using a gradient descent algorithm, LSPs for a given excitation are optimized to minim...

Abs t rac t . We show how real-time schedulability tests and program refinement rules can be integrated to create a formal development method of practical use to real-time programmers. A computational model for representing task scheduling is developed within a 'timed' refinement calculus. Proven multi-tasking schedulability tests then become available as feasibility checks during system refine...

We have recently described that sustained Plasmodium falciparum growth could be obtained in immunodeficient mice. We now report the potential of this new mouse model by assaying the effect of the passive transfer of antibodies (Abs) which in humans have had a well-established effect.Our results show that the total African adult hyperimmune immunoglobulin Gs (HI-IgGs) strongly reduce P. falcipar...

In this paper we introduce a multi-step linear Dyna-style planning algorithm. The key element of the multi-step linear Dyna is a multi-step linear model that enables multi-step projection of a sampled feature and multi-step planning based on the simulated multi-step transition experience. We propose two multi-step linear models. The first iterates the one-step linear model, but is generally com...

We have recently described that sustained Plasmodium falciparum growth could be obtained in immunodeficient mice. We now report the potential of this new mouse model by assaying the effect of the passive transfer of antibodies (Abs) which in humans have had a well-established effect. Our results show that the total African adult hyperimmune immunoglobulin Gs (HI-IgGs) strongly reduce P. falcipa...

Abs t r ac t . This paper presents an analysis-by-image-synthesis framework of shape and pose estimation of 3D multi-part objects, whose purpose is to map objects in the real world into virtual environments. In general, complex 3D multi-part objects cause serious self-occlusion and non-rigid motion. To deal with the occlusion among them, we employ both multiple calibrated cameras and time-varyi...

Dyna planning is an efficient way of learning from real and imaginary experience. Existing tabular and linear Dyna algorithms are single-step, because an “imaginary” feature is predicted only one step into the future. In this paper, we introduce a multi-step Dyna planning that predicts more steps into the future. Multi-step Dyna is able to figure out a sequence of multi-step results when a real...

OBJECTIVE To develop and validate a clinical tool based on the biomechanical strategies exhibited by people with hemiparesis due to stroke during the performance of the Timed "Up and Go" test. DESIGN/METHODS The Timed "Up and Go" Assessment of Biomechanical Strategies (TUG-ABS) was developed for subjects with stroke, based on the analyses of 3 sources of information: published evidence; opini...