a very efficient one-pot three-component synthesis of pyran derivatives has been improved by condensation of aldehydes and malononitrile with dimedone under 80 °c using sucrose as natural and biodegradable catalyst in water. this method offers some advantages including inexpensive, high to quantitative yields, short reaction time, and easy work-up. therefore, this methodology is entirely green ...

Multicomponent reactions (MCRs) represent very interesting tools to reach eco-friendly and sustainable transformations in organic chemistry. In particular, the Biginelli reaction furnishes a easy approach synthesis of library biological active compounds an academic course. Here we describe realization several experiments involving potential inhibitors ?-secretase by reaction. All obtained were ...

eggshell was found to be a versatile heterogeneous catalyst for the synthesis of pyrano[3,2-c]quinoline derivatives in good yields. this protocol has the advantages of environmental friendliness, short reaction time, low cost and convenient operation.

bis(indolyl)methanes are important group of bioactive metabolites of terrestrial and marine regions. they were synthesized by different methods. herein, a clean, one-pot synthesis of bis(indolyl)methane derivatives by cyclo-condensation reaction of indole and various aldehydes using sulfonic acid functionalized silica (sio2-pr-so3h) in aqueous media is reported. the advantages of this new metho...

We consider production technologies in which several parallel component processes are characterized by both component-specific and shared inputs outputs. The recently developed multicomponent variable constant returns-to-scale (MVRS MCRS) models of such based on the assumption that we have no information about actual allocation outputs to processes, is a common scenario many applications. MVRS ...

Synthesis of organic compounds using nano-catalysts is more and more attention due to the numerous advantages such as cost-effectiveness, high catalytic activity, ease of product separation, recovery of the catalyst, repeated recycling potential and good stability. In this work, TiCl2/nano-γ-Al2O3, as a novel type of green heterogeneous solid acid was prepared by the immobilization of TiCl2 on ...

an efficient and direct procedure for the synthesis of benzo[h]-indeno[1,2-b]-quinoline derivatives has been described. the procedure employs a three-component condensation reaction in one-pot using 2h-indene-1, 3-dione, naphthalen-1-amine,and aldehydes in the presence of catalytic amount of l-prolinein aqueous media.

Chemistry as a central science is facing a steadily increasing demand for new chemical entities (NCE). Innovative solutions, in all kinds of disciplines that depend on chemistry, require new molecules with specific properties, and their societal consequences are fundamental and pioneering. However, NCE not only demand a realistic structural space but also their feasibility poses challenges to s...