نتایج جستجو برای: multidrug resistant

تعداد نتایج: 202417  

2015
Helen S Cox Jennifer J Furin Carole D Mitnick Colleen Daniels Vivian Cox Eric Goemaere

Approximately half a million people are thought to develop multidrug-resistant tuberculosis annually. Barely 20% of these people currently receive recommended treatment and only about 10% are successfully treated. Poor access to treatment is probably driving the current epidemic, via ongoing transmission. Treatment scale-up is hampered by current treatment regimens, which are lengthy, expensive...

Journal: :iranian journal of pharmaceutical research 0
mohammad reza javadi department of clinical pharmacy, school of pharmacy, tehran university of medical sciences, tehran, iran. bahareh abtahi school of pharmacy, shahid beheshti university of medical sciences, tehran, iran. kheirollah gholami department of clinical pharmacy, school of pharmacy, tehran university of medical sciences, tehran, iran. behzad safari moghadam school of pharmacy, shahid beheshti university of medical sciences, tehran, iran. payam tabarsi national research institute of tuberculosis and lung diseases, masih daneshvari hospital, shahid beheshti university of medical sciences, tehran, iran. jamshid salamzadeh school of pharmacy, shahid beheshti university of medical sciences, tehran, iran.

amikacin has been shown to irreversibly suppresscochlear activity.the aim of this study is to assess the incidence of amikacinototoxicity in multidrug-resistant tuberculosis patients and riskfactors associated withthis ototoxicity.in this cross-sectional study, 41 patientswith multidrug-resistant tuberculosis (mdr-tb) were included.all patients received fixed dose of intravenous amikacin(500 mg...

Journal: :vaccine research 0
sh yari tuberculosis department, pasteur institute of iran, tehran, iran, microbiology research center (mrc), pasteur institute of iran, tehran, iran. ar hadizadeh tasbiti tuberculosis department, pasteur institute of iran, tehran, iran, microbiology research center (mrc), pasteur institute of iran, tehran, iran. m ghanei tuberculosis department, pasteur institute of iran, tehran, iran, chemical injury research center, baqiyatallah university of medical sciences, tehran, iran. ma shokrgozar national cell bank of iran, pasteur institute of iran, tehran, iran. r mahdian molecular medicine, biotechnology department, pasteur institute of iran, tehran, iran. a fateh tuberculosis department, pasteur institute of iran, tehran, iran, microbiology research center (mrc), pasteur institute of iran, tehran, iran.

introduction: tuberculosis (tb) remains a deadly infectious disease despite all the efforts to reduce its incidence. spread of multidrug resistant tb has seriously undermined the efforts to control the disease globally. in this study protein expression profile of mdr and sensitive isolates of mtb were analyzed and compared in order to identify proteins, which could be used in prevention, diagno...

Journal: :iranian journal of microbiology 0
hamidreza goli drug applied research center, faculty of medicine, tabriz university of medical sciences, tabriz, iran and department of medical microbiology, faculty of medicine, tabriz university of medical sciences, tabriz, iran. mohammadreza nahaei drug applied research center, faculty of medicine, tabriz university of medical sciences, tabriz, iran and department of medical microbiology, faculty of medicine, tabriz university of medical sciences, tabriz, iran. mohammad ahangarzadeh-rezaee infectious diseases and tropical medicine research center , faculty of medicine, tabriz university of medical sciences, tabriz, iran and department of medical microbiology, faculty of medicine, tabriz university of medical sciences, tabriz, iran. alka hasani infectious diseases and tropical medicine research center , faculty of medicine, tabriz university of medical sciences, tabriz, iran and department of medical microbiology, faculty of medicine, tabriz university of medical sciences, tabriz, iran. hossein samadi kafil drug applied research center, faculty of medicine, tabriz university of medical sciences, tabriz, iran and department of medical microbiology, faculty of medicine, tabriz university of medical sciences, tabriz, iran. mohammad aghazadeh drug applied research center, faculty of medicine, tabriz university of medical sciences, tabriz, iran and department of medical microbiology, faculty of medicine, tabriz university of medical sciences, tabriz, iran.

background and objectives: the prevalence of multidrug resistant pseudomonas aeruginosa is the main reason of new drugs resurgence such as colistin. the main objectives of this study were to determine the antibiotic resistance pattern and the rate of colistin resistance along with its correlation with overexpression of mexab-oprm and mexxy-oprm efflux pumps among p. aeruginosa isolates. materia...

2016
Dylan B. Tierney Meredith B. Milstein Justin Manjourides Jennifer J. Furin Carole D. Mitnick

Treatment outcomes for adolescents with multidrug-resistant tuberculosis are rarely reported and, to date, have been poor. Among 90 adolescents from Lima, Peru, 68 (75.6%) achieved cure or completion of treatment. Unsuccessful treatment was less common in the Peru cohort than previously described in the literature.

Bacterial infections may cause disease and death. Infants and children are often subject to bacterial infections. Antimicrobials kill bacteria protecting the infected patients andreducing the risk of morbidity and mortality caused by bacteria. The antibiotics may lose their antibacterial activity when they become resistant to a bacteria. The resistance to different antibiotics in a bacteria is ...

2006
Eva Nathanson Catharina Lambregts-van Weezenbeek Michael L. Rich Rajesh Gupta Jaime Bayona Kai Blöndal José A. Caminero J. Peter Cegielski Manfred Danilovits Marcos A. Espinal Vahur Hollo Ernesto Jaramillo Vaira Leimane Carole D. Mitnick Joia S. Mukherjee Paul Nunn Alexander Pasechnikov Thelma Tupasi Charles Wells Mario C. Raviglione

Evidence of successful management of multidrug-resistant tuberculosis (MDRTB) is mainly generated from referral hospitals in high-income countries. We evaluate the management of MDRTB in 5 resource-limited countries: Estonia, Latvia, Peru, the Philippines, and the Russian Federation. All projects were approved by the Green Light Committee for access to quality-assured second-line drugs provided...

Journal: :archives of pediatric infectious diseases 0
payam tabarsi clinical tb and epidemiology research center, national research institute of tuberculosis and lung diseases, shahid beheshti university of medical sciences, tehran, ir iran. tel/fax: +98-2126109590 ; clinical tb and epidemiology research center, national research institute of tuberculosis and lung diseases, shahid beheshti university of medical sciences, tehran, ir iranسازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (shahid beheshti university of medical sciences) davood yadegarinia iranian infectious disease research center, shahid beheshti university of medical sciences, tehran, ir iranسازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (shahid beheshti university of medical sciences)

multidrug-resistant (mdr) and extensively drug-resistant (xdr) tuberculosis (tb) are increasing globally. treatment options for these patients are very limited. although treatment of these patients with standardized regimen is associated with high mortality and morbidity, rational usage of new drugs might be promising. in this study we will review epidemiology of xdr-tb and tdr-tb in iran and t...

Journal: :Science 2002
Christopher Dye Brian G Williams Marcos A Espinal Mario C Raviglione

Multidrug-resistant tuberculosis (MDR) is perceived as a growing hazard to human health worldwide. Judgments about the true scale of the problem, and strategies for containing it, need to come from a balanced appraisal of the epidemiological evidence. We conclude in this review that MDR is, and will probably remain, a locally severe problem; that epidemics can be prevented by fully exploiting t...

Journal: :The European respiratory journal 2015
Karapet Davtyan Armen Hayrapetyan Masoud Dara Laura Gillini Hayk Davtyan Rosella Centis Lia D'Ambrosio Giovanni Sotgiu Giovanni Battista Migliori

linezolid in multidrug-resistant and extensively drug-resistant tuberculosis patients. Clin Pharmacokinet 2010; 49: 559–565. 9 Koh WJ, Kang YR, Jeon K, et al. Daily 300 mg dose of linezolid for multidrug-resistant and extensively drug-resistant tuberculosis: updated analysis of 51 patients. J Antimicrob Chemother 2012; 67: 1503–1507. 10 Srivastava S, Peloquin CA, Sotgiu G, et al. Therapeutic dr...

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