OBJECTIVES To investigate a multimodal, multiparametric perfusion MRI / 18F-fluoro-deoxyglucose-(18F-FDG)-PET imaging protocol for monitoring regorafenib therapy effects on experimental colorectal adenocarcinomas in rats with immunohistochemical validation. MATERIALS AND METHODS Human colorectal adenocarcinoma xenografts (HT-29) were implanted subcutaneously in n = 17 (n = 10 therapy group; n...

Materials and Methods. In this article, we present a computer-assisted WML segmentation method, based on local f tures extracted from multiparametric magnetic resonance imaging (MRI) sequences (ie, T1-weighted, T2-weighted, pro density-weighted, and fluid attenuation inversion recovery MRI scans). A support vector machine classifier is first tr on expert-defined WMLs, and is then used to classi...

Fully integrated positron emission tomography (PET)/magnetic resonance imaging (MRI) scanners have been available for a few years. Since then, the number of scanner installations and published studies have been growing. While feasibility of integrated PET/MRI has been demonstrated for many clinical and preclinical imaging applications, now those applications where PET/MRI provides a clear benef...

In this study, a multiparametric magnetic resonance image (MRI) based technique of detecting prostate cancer is developed. A machine learning algorithm, based on random forest is used to classify the normal and cancer regions. Three features extracted from dynamic contrast enhanced MRI and two features extracted from diffusion tensor MRI is used to train the classifier. The classifier is traine...

The migration of cells within a living organism can be observed with magnetic resonance imaging (MRI) in combination with iron oxide nanoparticles as an intracellular contrast agent. This method, however, suffers from low sensitivity and specificty. Here, we developed a quantitative non-invasive in-vivo cell localization method using contrast enhanced multiparametric MRI and support vector mach...