نتایج جستجو برای: mune
تعداد نتایج: 196 فیلتر نتایج به سال:
Motor unit number estimation (MUNE), is a method developed to determine the numbers of motor axons to the best possible quantity. In this study, we aimed to test the MUNE in different age groups in the normal population. This study was done on healthy volunteers who had not neither peripheral nerve nor systemic/ metabolic disease, and had a normal neurological examination. All had normal median...
Background: 5q-Spinal Muscular Atrophy (SMA) is one of the most prevalent neuromuscular diseases in our country, and still an important cause lethality, due to genetic disease, its severe forms. From a point view, it already known that number copies SMN2 gene drastically influences phenotype inverse relationship with severity disease. Several studies show reduction motor unit counts by differen...
Clinical and pathologic features of myasthenia gravis suggest a possible autoim mune etiology. Myasthenia is found in association with other putative autoim mune diseases and autoantibodies including anti-muscle antibodies. There is also in vitro evidence for cell-mediated immunity to muscle in blood and thymic cells as well as a suggestion of antigenic disparity between blood and thymic cell...
OBJECTIVES There is a need for better, noninvasive quantitative biomarkers for assessing the rate of progression and possible response to therapy in spinal muscular atrophy (SMA). In this study, we compared three electrophysiological measures: compound muscle action potential (CMAP) amplitude, motor unit number estimate (MUNE), and electrical impedance myography (EIM) 50 kHz phase values in a m...
OBJECTIVE To compare electrical impedance myography (EIM) 50 kHz phase to weight, motor score, paw grip endurance (PGE), CMAP amplitude, and MUNE for the identification of disease progression and the effect of riluzole in the SOD1 G93A mouse. METHODS Twenty-three animals received 8 mg/kg/day riluzole in the drinking water starting at 6 weeks of age; 22 animals served as controls. Weight, moto...
In the present study, the adapted multiple point stimulation (AMPS) method was first applied to median innervated thenar muscles in 22 amyotrophic lateral sclerosis (ALS) patients who did not received any treatment. In all patients, a motor unit number estimate (MUNE) and an average surface-recorded motor unit action potential (S-MUAP) size have been derived even if the denervation was severe; ...
Decomposition-enhanced spike-triggered averaging (DE-STA) has been developed as a method for obtaining a motor unit number estimate (MUNE). We describe the method and report control data for the first dorsal interosseous/adductor pollicis and thenar muscles and reliability in the thenar muscles. Seventeen subjects (ages 20-50 years) took part in the study. The maximum M potential was elicited w...
OBJECTIVE To establish within-subject reliability of motor unit number estimates (MUNEs) and quantitative MU analysis using decomposition-based quantitative electromyography (DQEMG). METHODS Following the acquisition of a maximum M-wave, needle and surface-detected EMG signals were collected during contractions of the first dorsal interrosseous (FDI) and biceps brachii (BB). DQEMG was used to...
OBJECTIVE To investigate the value of objective biomarkers for upper (UMN) and lower (LMN) motor neuron involvement in ALS. METHODS We prospectively studied 64 patients with ALS and its subsets using clinical measures, proton MR spectroscopic imaging ((1)H MRSI), diffusion tensor imaging, transcranial magnetic stimulation, and the motor unit number estimation (MUNE) at baseline and every 3 mo...
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