Background and purpose: Polycaprolactone nanocapsules incorporated with triazole derivatives in the presence absence of selenium nanoparticles were prepared evaluated as antiproli­ferative anticancer agents. using emulsion technique. Experimental approach: The capsules characterized FT-IR, TEM DLS measurements. synthesized triazo­lopyrimidine derivative encap­sulated polycaprolactone was tested...

Herein, we report on the synthesis and characterization of ruthenium compounds with general formula [RuCl(AA-H)(NO)(dppb]PF6, where AA = glycine (1), L-alanine (2), L-phenylalanine (3) L-valine (4), dppb 1,4-bis(diphenylphosphine)butane. The complexes were characterized using elemental analysis, UV/Vis infrared spectroscopies, 1H, 13C, 31P NMR techniques, cyclic voltammetry. Furthermore, struct...

Oncostatin M (OSM) is a member of the IL-6/LIF (or gp130) cytokine family, and its potential role in inflammation is supported by a number of activities identified in vitro. In this study, we investigate the action of murine OSM on expression of the CC chemokine eotaxin by fibroblasts in vitro and on mouse lung tissue in vivo. Recombinant murine OSM stimulated eotaxin protein production and mRN...

The calcium/calmodulin-gated KCa3.1 channel regulates normal and abnormal mitogenesis by controlling K+-efflux, cell volume, and membrane hyperpolarization-driven calcium-entry. Recent studies suggest modulation of KCa3.1 by omega-3 fatty acids as negative modulators and impaired KCa3.1 functions in the inherited lysosomal storage disorder (LSD), Fabry disease (FD). In the first part of present...

background: mdm2 (murine double minute2) is an oncoprotein that inhibits the p53 activity. overexpression of mdm2 gene has been reported in several human tumors. in the present study, we aimed to evaluate the impact of 40-bp insertion/deletion (ins/del) polymorphism on the promoter of mdm2 and susceptibility to breast cancer in a sample of iranian population. methods: this case-control study wa...

INTRODUCTION Synovial fibroblasts invade cartilage and bone, leading to joint destruction in rheumatoid arthritis. However, the mechanisms that regulate synovial fibroblast invasion are not well understood. Focal adhesion kinase (FAK) has been implicated in cellular invasion in several cell types, and FAK inhibitors are in clinical trials for cancer treatment. Little is known about the role of ...

Sulfated polysaccharides isolated from seaweeds are thought of as ideal ingredients in the pharmaceutical, nutraceutical, and cosmetics industries. Our previous study characterized sulfated Padina boryana. The boryana (PBP) were extracted, antioxidant activity PBP was evaluated. results indicate that possesses effects potential cosmetic industry. To further investigate cosmetics, photoprotectiv...