PURPOSE The present study investigated the effects of acid and mixed reflux on the responsiveness of gastric smooth muscle in the gastroesophageal reflux (GER) rat model. MATERIAL AND METHODS Three groups of rat were studied encompassing acid reflux, mixed reflux and sham operation. Acid reflux was induced by pyloric ligation (AR group) and mixed reflux was induced by jejunal ligation 1 cm di...

background: n-acetylcysteine (nac) has been indicated against experimental seizures, but with relatively inconclusive results. this study was undertaken to evaluate whether nac exerts a dose-dependent anticonvulsant effect and to determine nac safe therapeutic dose range and its muscle-relaxant activity in both acute and chronic uses. methods: following intraperitoneal (i.p.) administration of ...

Correspondence: Sorin J Brull Department of Anesthesiology, Mayo Clinic College of Medicine, 4500 San Pablo road, Jacksonville, FL 32224, USA Tel +1 904 956 3331 Fax +1 904 956 3332 email [email protected] Abstract: Despite the significant improvements in the pharmacology of muscle relaxants in the past six decades, the search for the ideal muscle relaxant continues, mainly because of the inc...

I originally took a muscle relaxer because I was experiencing very bad back pain and could not sleep. I was not prescribed the muscle relaxers. My friend suggested I take one of hers. So I did, and now I will take one sometimes before bed if I can't fall asleep or if I want to actually just relax. It makes me just want to sleep, and I feel really calm after taking one. Is this bad that I take t...

Hayatin methiodide has been used as a muscle relaxant during surgery in 100 patients. This drug provided adequate relaxation for endotracheal intubation and surgery. It appeared to be about one-third as potent as tubocurarine. The duration of both these drugs was of equal magnitude in equipotent doses. The neuromuscular block produced by this drug could be completely reversed by neostigmine. It...

Despite the significant improvements in the pharmacology of muscle relaxants in the past six decades, the search for the ideal muscle relaxant continues, mainly because of the incomplete efficacy and persistent side effects associated with their antagonism. Clinical concerns remain about the residual paralysis and hemodynamic side effects associated with the classic pharmacologic reversal agent...

Aging has been reported to cause impotence, the mechanism of which is unknown. Therefore, we investigated the effect of aging on electrical stimulation-induced neurogenic, carbachol-induced, endothelium-dependent, and sodium nitroprusside-induced cGMP-dependent relaxant responses of rabbit corporal smooth muscle. Male New Zealand white rabbits were divided into young (4 months), intermediate (8...

I originally took a muscle relaxer because I was experiencing very bad back pain and could not sleep. I was not prescribed the muscle relaxers. My friend suggested I take one of hers. So I did, and now I will take one sometimes before bed if I can't fall asleep or if I want to actually just relax. It makes me just want to sleep, and I feel really calm after taking one. Is this bad that I take t...

The first goal of this study was to examine the effect of secondhand smoking on neurogenic, endothelium- and cGMP-dependent relaxant responses of rabbit corpus cavernosum smooth muscle. Our second goal was to determine whether such an effect can be prevented by oral administration of L-arginine. Male New Zealand rabbits were divided into control, chronic passive cigarette smoking and L-arginine...