objective this study was undertaken to evaluate the clinical spectrum of myasthenia gravis in children and determine factors that help the clinician in his/her diagnosis and management. materials & methods a retrospective review was performed on all pediatric patients suffering from myasthenia gravis (m.g) admitted in the department of pediatric neurology of the mofid hospital of the shaheed be...

Myasthenia gravis (Paralysis Suna non Habitualis) is a neuromuscular disease, characterized by fluctuating weakness of skeletal muscles, which is increased by use, at least partially relieved by rest and improves specifically by anticholinesterases. Myasthenic crisis is a life threatening condition in which there is sudden failure in respiratory function due to muscle weakness. It starts with o...

BACKGROUND Castleman's disease (CD) is a relatively rare disorder characterized by the benign proliferation of lymphoid tissue. The combination of an occurrence of retroperitoneal pararenal CD with myasthenia gravis (MG) is extremely rare. CASE PRESENTATION The patient was admitted to our hospital for investigation of a retroperitoneal pararenal tumor which had been coincidentally diagnosed a...

INTRODUCTION Although myasthenia gravis is frequently associated with other disorders, it has not been reported together with primary sclerosing cholangitis, complicating the administration of liver-toxic immunosuppressive therapy. CASE PRESENTATION A 73-year-old Caucasian woman with a history of arterial hypertension, thyroid dysfunction, glaucoma, right-sided ptosis and later generalized we...

The prevalence of myasthenia gravis is low. The management implications of this disease in pregnant women are very challenging for anaesthetists. The objective is to highlight some of the challenges, the management and the lessons learnt during the management of this patient. This is a case report of a 31-year old parturient with diagnosed myasthenia gravis co-existing with hepatitis B infectio...

Myasthenia gravis (MG) is an autoimmune disorder of neuromuscular transmission, characterized by fluctuating weakness in certain skeletal muscles.1 The reported prevalence of MG (5–20/100,000 individuals) has been continually increasing.2-5 The clinical courses of patients with MG are quite diverse, from complete remission to MGrelated death.6 MG crisis, defined as an exacerbation of MG requiri...

We described a case of a patient with autosomal dominant progressive external ophthalmoplegia (PEO) who presented with the acute onset dysphagia, quadriparesis, ptosis and respiratory insufficiency following a cardiac procedure and mimicking a myasthenic crisis. A pathogenic mutation in the C10orf2 (PEO1) gene was confirmed. The unusual presentation of our patient contributes to expand the clin...

We describe a case of recurrent invasive thymoma associated with myasthenia gravis that responded to combined treatment with prednisolone and tacrolimus. The patient suffered from a myasthenic crisis and received methylprednisolone pulse therapy and partial thymomectomy. Low maintenance doses of prednisolone and tacrolimus shrank the size of the invasive thymoma and maintained the patient witho...

A 34 year old female with undiagnosed myasthenia gravis (MG) presented with shortness of breath and weakness. She was diagnosed with community acquired pneumonia and myasthenic crisis (MC). Her hospital course was complicated by hypoxemic respiratory failure requiring intubation with echocardiography revealing a hyper-dynamic apex and basilar hypokinesis consistent with Reverse Takotsubo Cardio...