Basic fibroblast growth factor (bFGF), a member of the fibroblast growth factor family, potently induces increased vascular smooth muscle cell (SMC) proliferation and decreased expression of type I collagen. Recently, our laboratory demonstrated that, in bovine vascular SMCs, expression of B-myb, a member of the myb gene family, is dependent upon cellular growth state and that B-myb decreases a...

artemisia annua is an annual herb native to asia most probably china produce one of the most important sesquiterpene namely artemisinin which has antimalarial and anticancer activity. three transcription factors belonging to wrky family, two transcription factors belonging to myb family and two enzymes dbr2 and opr3 were isolated from a.  annua leaves and first inserted into pjet1.2 vector then...

The development of blood cells proceeds from pluripotent stem cells through multipotent progenitors into mature elements belonging to at least 8 different lineages. The lineage choice process during which stem cells and progenitors commit to a particular lineage is regulated by a coordinated action of extracellular signals and transcription factors. Molecular mechanisms controlling commitment a...

The c-Myb transcription factor is important for fetal hematopoiesis and has been proposed to mediate later stages of lymphocyte development. Using homozygous null c-Myb/Rag1 chimeric mice, we have determined that c-Myb plays an important role in the differentiation of macrophages and lymphocytes from precursor stem cells. We also determine that deletion of c-Myb leads to a complete block in ear...

Anthocyanin is a class of water-soluble flavonoids found in Chinese bayberry (Morella rubra) that not only responsible for the variety colors visible nature but also has numerous health-promoting benefits humans. Through comparative transcriptomics, we isolated and identified transcription factor (TF) R2R3-MYB type, MrMYB9, order to explore anthocyanin biosynthesis pathway red white bayberries....

Abstract Cassava (Manihot esculenta Crantz) is worldwide the sixth-largest food crop and highly drought resistant. The expression of myeloblastosis (MYB) family protein MeMYB26 in cassava was previously reported to be significantly up-regulated under water deficit. To study basic characterization, natural variations potential functions for resistance cassava, subjected bioinformatics analysis, ...

The c-Myb transcription factor regulates the differentiation of immature erythroid, lymphoid, and myeloid cells, although only the latter cells become transformed by the v-myb oncogene. These are also the only cells that express the Myb-regulated gene mim-1, suggesting that Myb requires tissue-specific, cooperating factors to activate such genes. Here, we investigated the tissue-specific regula...

MYB transcription factor family is one of the largest families in the plant kingdom, specifically characterized by a Helix-turn-helix domain in their structural configuration with two repeats of R2R3 MYB domain and are known for regulating plant stress tolerance (abiotic and biotic) through ABA dependent signaling systems. R2R3MYB family transcription factors plays a role in the regulation of s...

The c-myb protooncogene encodes a highly conserved transcription factor that functions as both an activator and a repressor of transcription. The v-myb oncogenes of E26 leukemia virus and avian myeloblastosis virus encode proteins that are truncated at both the amino and the carboxyl terminus, deleting portions of the c-Myb DNA-binding and negative regulatory domains. This has led to speculatio...

A transcription factor of the Myb family has been found to couple dorsoventral patterning and proximodistal outgrowth during leaf development.