نتایج جستجو برای: mycobacterium vaccae

تعداد نتایج: 46204  

2007
S. L. LIGHTMAN

bstract—Peripheral immune activation can have profound hysiological and behavioral effects including induction of ever and sickness behavior. One mechanism through which mmune activation or immunomodulation may affect physiolgy and behavior is via actions on brainstem neuromodulaory systems, such as serotonergic systems. We have found hat peripheral immune activation with antigens derived from ...

Journal: :Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2000
R D Waddell C Chintu A D Lein A Zumla M R Karagas K S Baboo J D Habbema A N Tosteson P Morin S Tvaroha R D Arbeit A Mwinga C F von Reyn

Five doses of inactivated Mycobacterium vaccae vaccine were administered intradermally to 22 human immunodeficiency virus (HIV)-infected patients (11 bacille Calmette-Guérin [BCG]-positive and 11 BCG-negative) in Zambia whose CD4 lymphocyte counts were >/=200 cells/mm(3). HIV viral load and lymphocyte proliferation responses were compared for vaccine recipients and 22 HIV-infected control patie...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2016
Stefan O Reber Philip H Siebler Nina C Donner James T Morton David G Smith Jared M Kopelman Kenneth R Lowe Kristen J Wheeler James H Fox James E Hassell Benjamin N Greenwood Charline Jansch Anja Lechner Dominic Schmidt Nicole Uschold-Schmidt Andrea M Füchsl Dominik Langgartner Frederick R Walker Matthew W Hale Gerardo Lopez Perez Will Van Treuren Antonio González Andrea L Halweg-Edwards Monika Fleshner Charles L Raison Graham A Rook Shyamal D Peddada Rob Knight Christopher A Lowry

The prevalence of inflammatory diseases is increasing in modern urban societies. Inflammation increases risk of stress-related pathology; consequently, immunoregulatory or antiinflammatory approaches may protect against negative stress-related outcomes. We show that stress disrupts the homeostatic relationship between the microbiota and the host, resulting in exaggerated inflammation. Repeated ...

2016
Pere-Joan Cardona

A major problem with tuberculosis (TB) control is the long duration of drug therapy-both for latent and for active TB. Therapeutic vaccination has been postulated to improve this situation, and to this end there are several candidates already in clinical phases of development. These candidates follow two main designs, namely bacilli-directed therapy based on inactivated -whole or -fragmented ba...

2007
C.A. Lowry J.H. Hollis A. de Vries B. Pan L.R. Brunet J.R.F. Hunt J.F.R. Paton E. van Kampen D.M. Knight A.K. Evans G.A.W. Rook S.L. Lightman

Peripheral immune activation can have profound physiological and behavioral effects including induction of fever and sickness behavior. One mechanism through which immune activation or immunomodulation may affect physiology and behavior is via actions on brainstem neuromodulatory systems, such as serotonergic systems. We have found that peripheral immune activation with antigens derived from th...

Journal: : 2021

Prokaryotes of the genus Mycobacterium occupy an important evolutionary and historical place in system microorganisms prokaryotic eukaryotic organization Earth's biosphere. These are most ancient that have passed a long path mutual adaptation with evolving biosphere over billions years. Antiquity origin is very process developing stable at same time adaptive genomic apparatus, which provides ge...

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