Mycosis fungoides is a low-grade cutaneous T-cell lymphoma. Early treatment often involves the use of topical chemotherapy such as mechlorethamine or carmustine although single-agent oral chemotherapy with alkylators is common for advanced disease. Recently, in a Phase I study of the new alkylating agent temozolomide, two mycosis fungoides patients experienced a complete response. The mechanism...

The most common cutaneous lymphoma is known historically as mycosis fungoides (MF), and represents about 50-60% of all cutaneous lymphomas. The broader term “cutaneous T-cell lymphoma” has also been applied to mycosis fungoides and related conditions such as Sezary syndrome, but it is important to recognize that there are several forms of T-cell lymphoma in the skin unrelated to mycosis fungoid...

About 75% of cutaneous lymphomas belong to the group of T-cell lymphomas. Mycosis fungoides is the most common entity in this group. Granulomatous slack skin is a rare form of cutaneous T-cell lymphoma closely related to mycosis fungoides. We present here a patient with areas of lax skin for several years who developed a generalized erythroderma with associated immunoactivation and a deteriorat...

A 71-year-old man presented with numerous pruritic seborrheic keratoses, with an eruptive onset over the course of 3 months. At presentation, he was also found to have hypopigmented tumors diffusely scattered throughout his body that were found to be mycosis fungoides on histologic examination. A theory regarding the pathophysiology of the development of eruptive seborrheic keratoses in the pre...

Just as mycosis fungoides is a disease with many different clinical and histologic manifestations, so too are there many inflammatory conditions that mimic this cutaneous lymphoma. Sometimes the best way to “rule out” a diagnosis of mycosis fungoides is to make a firm diagnosis of another condition. The following entities may be confused with mycosis fungoides on histologic grounds, and represe...

Melanocytic nevi represent a widespread cutaneous finding. Nevertheless, the presence of mycosis fungoides and melanocytic nevi in the same location is an extremely rare event. We report the case of a patient affected by mycosis fungoides and treated with PUVA therapy, with complete remission of the disease. Eight years after therapy discontinuation, he presented epidermal scaling and an erythe...

261 Hematol 2011;86:928-48. 2. Jawed SI, Myskowski PL, Horwitz S, et al. Primary cutaneous T-cell lymphoma (mycosis fungoides and Sézary syndrome): part I. Diagnosis: clinical and histopathologic features and new molecular and biologic markers. J Am Acad Dermatol 2014;70:205.e1-16. 3. Arafah M, Zaidi SN, Kfoury HK, et al. The histological spectrum of early mycosis fungoides: a study of 58 Saudi...

A patient with advanced mycosis fungoides developed neurologic and respiratory symptoms and signs following multiple courses of chemotherapy and radiotherapy. Various repeated diagnostic procedures--including cranial computerized tomography and fiberoptic bronchoscopy with transbronchial lung biopsy--failed to demonstrate an unusual involvement of the brain and lungs by mycosis fungoides. Radio...

Mycosis fungoides is the most common type of cutaneous T-cell lymphoma. There are a wide range of treatments for early-stage and advanced-stage mycosis fungoides. Photodynamic therapy (PDT) has emerged as a new treatment modality due to its safety and efficacy. The aim of this study was to investigate the safety and efficacy of PDT with methyl-aminolaevulinic acid (MAL) for the treatment of myc...

Methotrexate-induced cutaneous ulceration is a rare but potentially serious drug adverse reaction. This adverse reaction of methotrexate therapy has been initially described in psoriasis patients and is unusual in patients with cutaneous T-cell lymphoma. In 1978, Mc Donald et al reported the first three cases of cutaneous ulcerations in patients treated for a mycosis fungoides with intravenous ...