AIMS Characterization of pulmonary hypertension (PH) and the effects of myectomy in hypertrophic cardiomyopathy (HCM) remain poorly defined. The aim of the study was to investigate the effect of myectomy on PH in HCM. METHODS AND RESULTS This is a retrospective analysis of 306 consecutive symptomatic HCM patients (70% NYHA class III-IV) with evaluation of echocardiographic right ventricular s...

Method Between 2010 and 2014, 182 patients underwent of extended myectomy procedures. 70 patient met inclusion criteria: were randomly assigned to receive MSA intervention in addition to septal myectomy (MSI group; n = 36) or undergo septal myectomy only (without MSI group; n = 34). A primary HOCM was the main indication for surgery according to 2011 ACCF/AHA guidelines. Mean age was 52.8 ± 14....

Background Hypertrophic cardiomyopathy is a genetic disease of the myocardial sarcolemma characterized by left ventricular hypertrophy. When obstruction to the left ventricular outflow tract is present and symptoms are refractory to medication, surgical myectomy or alcohol septal ablation is indicated. Case Description We report a case of a patient presented for myectomy due to recurrence only ...

AIM The aim of the study was to compare the functional and structural properties of the motor protein, myosin, and isolated myocyte contractility in heart muscle excised from hypertrophic cardiomyopathy patients by surgical myectomy with explanted failing heart and non-failing donor heart muscle. METHODS Myosin was isolated and studied using an in vitro motility assay. The distribution of myo...

Objectives Septal myectomy confers survival benefits on patients with hypertrophic cardiomyopathy. However, its role in the treatment of severe aortic stenosis (sAS) left ventricular outflow tract obstruction (LVOTO) remains under investigation. Another challenging question era transcatheter valve replacement is who would benefit more from traditional surgical (SAVR) myectomy. Therefore, this s...

OBJECTIVES To determine the effects of upper-eyelid surgery (limited myectomy, blepharoplasty, and levator aponeurotic advancement) on patients who demonstrated a suboptimal response or residual heaviness of the upper eyelids after botulinum toxin eyelid injections for facial dyskinesia. DESIGN Retrospective study. SUBJECTS Charts of 358 patients with a diagnosis of benign essential blephar...

The complexity of the anatomical substrate that produces obstruction in hypertrophic obstructive cardiomyopathy (HOCM) is reflected by the variety of different surgical strategies that have been reported during the past 30 years[1–12]. These include incision (myotomy)[1] and excision (myectomy)[2,3] of bulging myocardial tissue from the basal septum, in some series together with plication[9] or...

BACKGROUND The clinical efficacy of alcohol septal ablation for drug-refractory hypertrophic cardiomyopathy remains unclear. This study examines the outcome of alcohol septal ablation performed at a tertiary hypertrophic cardiomyopathy referral center. METHODS AND RESULTS Among 601 patients with severely symptomatic obstructive hypertrophic cardiomyopathy referred for alcohol septal ablation ...

Background—The clinical efficacy of alcohol septal ablation for drug-refractory hypertrophic cardiomyopathy remains unclear. This study examines the outcome of alcohol septal ablation performed at a tertiary hypertrophic cardiomyopathy referral center. Methods and Results—Among 601 patients with severely symptomatic obstructive hypertrophic cardiomyopathy referred for alcohol septal ablation or...

OBJECTIVES Patients with hypertrophic obstructive cardiomyopathy and basal septal thickness <18 mm are often considered unsuitable candidates for myectomy. Mitral valve (MV) replacement is frequently performed instead. We aimed to determine whether septal thickness affects outcomes and adequacy of myectomy. METHODS Clinical and echocardiographic data were reviewed for 1486 consecutive adult p...