3 Introduction 3 Pathophysiological features of reperfusion injury 4 Metabolic changes in myocardial ischemia-reperfusion 7 Oxidative stress in myocardial ischemia-reperfusion 9 Types of antioxidants 11 Role of antioxidants in myocardial ischemia-reperfusion injury 12 Hypothesis 15 Hypothesis 1: Xanthine oxidase inhibitor can protect against myocardial ischemia-reperfusion injury. 15 Hypothesis...

in the current study, effects of acute short term administration of fructose on cardiac arrhythmias and myocardial infarction size following ischemia/reperfusion were investigated in isolated rat heart. the hearts were subjected to 30 min zero flow global ischemia followed by 120 min reperfusion. in the control group, the hearts were perfused by normal drug free krebs-henseleit (k/h) solution t...

Myocardial ischemia (MI) resulting in infarction is an important cause of mortality and morbidity worldwide. Acute ischaemia rapidly impairs myocardial contractile function. Myocardial dysfunction persisting for several hours after transient non-lethal ischaemia, eventually resulting in full functional recovery is termed as myocardial stunning. Hibernation is now thought to be...

conclusions the effect of diabetes mellitus on stroke was more significant than on ihd, and the effect of high ldl-c level was more significant on ihd than on stroke, other risk factors, including hypertension, have similar rrs for ihd and stroke. health care professionals need more training regarding the rrs of these risk factors in the iranian society, and health decision makers should consid...

conclusions gallic acid and csa combination improved antioxidant capacity and cell membrane integrity more than each one alone. therefore, it can be a therapeutic approach to reduce the i/r injury. background myocardial infarction is one of the important causes of death during old ages. gallic acid as an antioxidant or cyclosporine a (csa) as inhibitor of mitochondrial permeability transition p...

background: acute coronary syndrome is a life-threatening condition. considerable doubts exist over the effects of this disease on patients’ quality of life. the aim of this study was to survey quality of life and its influencing factors in patients with acute coronary syndrome. methods: a convenience sample of 300 patients with acute coronary syndrome was drawn from shahid beheshti hospital, k...

background: there is evidence that electrocardiographic (ecg) changes occur during elective cesarean section in parturients. these changes, mostly in the form of st-segment depression, have been noted in either regional anesthesia or general anesthesia. we performed this study to compare hemodynamic variables and electrocardiographic changes suggestive of myocardial ischemia following administr...

introduction: asymptomatic diabetic patients are at increased risk of cardiovascular complications. myocardial perfusion scan may be effective in risk evaluation in this population. methods: 106 asymptomatic diabetic patients (age: min: 37, max: 82, mean: 57.73±8.88), including 56 females (52.8%) and 50 males (47.2%) were enrolled in the study. myocardial perfusion scintigraphy was performed by...

Myocardial bridge is a benign congenital anomaly in which a segment of major epicardial coronary arteries descends into the myocardium for a variable distance. Myocardial bridge is most often single and located in the middle part of the left anterior descending artery. The presence of more than one myocardial bridge in coronary arteries is very rare. We present a patient with more than one myoc...

cardiovascular disease (cad) screening in asymptomatic patients with diabetes mellitus is controversial. an exercise stress test is a safe and effective initial testing for ischemic heart disease (ihd) screening. treadmill stress test is not the best screening method for a particular patient who is not able to exercise, abnormal electrocardiogram (ecg) or positive exercise treadmill test (ett) ...