background myocardial injury caused by ischemia-reperfusion leads to cardiac dysfunction, tissue injury and metabolic changes. the production of reactive oxygen species (ros) and lipid peroxidation are accompanied by ischemia-reperfusion injury. objectives the aim of this study was to assess the cardio protective potential effects of crocin in comparison with vitamin e on antioxidant capacity i...

OBJECT To investigate the effect of lung Ischemia-reperfusion injury on cardiac muscle. METHODS SD rats were randomly divided into the following four groups: sham operation group (TS group); experimental control group (TG group); curcumin group (TC group); dexamethasone group (TM group). After 4 h and 24 h of lung ischemia-reperfusion, the cardiac muscle was collected. We measured the concent...

Clinical studies have reported that the incidence and severity of myocardial infarction is significantly greater in diabetics compared with nondiabetics after correction for all other risk factors. The majority of studies investigating the pathophysiology of myocardial ischemia-reperfusion injury have focused on otherwise healthy animals. At present, there is a paucity of experimental investiga...

Myocardial sulfhydryl (SH)-containing compounds, including reduced glutathione (GSH), are both defenses against and potential markers of reactive oxygen metabolite injury during ischemia and reperfusion. We examined the alterations in GSH and other myocardial SH pools during reperfusion in anesthetized dogs exposed to brief (15 minutes, n = 7) or prolonged (90 minutes, n = 6) regional ischemia ...

Objective: Previous studies reported that asafetida from Ferula assa-foetida Linn. species and its essential oil (AEO) have antioxidant effects. In the present study, the effect of AEO was evaluated on ischemic-reperfusion injury in isolated rat hearts. Materials and Methods: Forty-eight male Wistar rats were divided into 6 groups: 1) control group, 2) vehicle group, 3-5) AEO groups and, 6) car...

Direct monitoring of myoglobin efflux during ischemia and reperfusion has been limited because of inherent sample collection problems in the ischemic region. Recently, the cardiac dialysis technique has offered a powerful method for monitoring myocardial interstitial levels of low-molecular-weight compounds in the cardiac ischemic region. In the present study, we extended the molecular target t...

global myocardial ischemia and ischemia-reperfusion injury are potential adverse events related with cardioplegic arrest. beating heart surgery has avoided such complications and adapted to valve surgery following successful results published on myocardial revascularization. difficulty in weaning from cardiopulmonary bypass may be lessened by using on-pump beating heart surgery for mitral valve...

Ischemia/reperfusion injury refers to the tissue damage which occurs when blood supply returns to tissue after a period of ischemia [1]. Clinically, patients with coronary artery disease are often subjected to coronary reperfusion after cardiac arrest, interventional recanalization, myocardial infarction, coronary spasm or thorombosis [2]. Recently, myocardial ischemia/reperfusion injury and it...

Myocardial ischemia/reperfusion injury affects not only the cardiomyocyte compartment but also all other cellular compartments, and the coronary circulation has a central role in it. Acute myocardial infarction most often arises from atherosclerotic plaque rupture/erosion with superimposed thrombosis (type 1 myocardial infarction). However, in the absence of coronary atherosclerosis, coronary v...

Ischemia-reperfusion syndrome is defined as myocardial injury caused by the restoration of coronary flow. This phenomenon has a complex pathophysiology and results in a paradoxical reduction of the beneficial effect of myocardial reperfusion. Studies suggest that ischemia-reperfusion injury may account for up to 50% of the final size of a myocardial infarct. Vastarel MR (trimetazidine) is a pha...