نتایج جستجو برای: myokine
تعداد نتایج: 312 فیلتر نتایج به سال:
Traumatic damage to the anterior cruciate ligament leads impaired support and mechanical instability of limb. One frequent complications after injury is arthrogenic muscle inhibition due quadriceps development functional contracture. On contrary, one indicators high activity a sufficient level in blood proteins – myokines, particular interleukin-6, which are expressed released by fibers. The ai...
Exercise remains the most effective way to promote physical and metabolic wellbeing, but molecular mechanisms underlying exercise tolerance and its plasticity are only partially understood. In this study we identify musclin-a peptide with high homology to natriuretic peptides (NP)-as an exercise-responsive myokine that acts to enhance exercise capacity in mice. We use human primary myoblast cul...
Irisin, a newly discovered myokine that reduces obesity and improve insulin resistance via the browning of white adipose tissues. Irisin is expressed and secreted in response to exercise, providing a hormonal link between exercise and improved insulin sensitivity. Several studies reported low irisin level in diabetic patient as compared to control. Therefore,it has been assumed that irisin may ...
Exercise can improve cognitive function and the outcome of neurodegenerative diseases, like Alzheimer's disease. This effect has been linked to the increased expression of brain-derived neurotrophic factor (BDNF). However, the underlying molecular mechanisms driving the elevation of this neurotrophin remain unknown. Recently, we have reported a PGC-1α-FNDC5/irisin pathway, which is activated by...
BACKGROUND Adrenomedullin, a recently identified myokine, has an anti-inflammatory effect. Therefore, we aimed to assess the correlation of adrenomedullin concentrations with the presence and grade of severity of knee osteoarthritis (OA). MATERIAL AND METHODS We recruited 187 knee OA patients and 109 healthy subjects. The severity of OA was evaluated using the Kellgren-Lawrence grading system. ...
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