introduction and aim: gastroesophageal reflux disease (gerd) and irritable bowel syndrome (ibs) are important diseases, which are increasing in frequency and capable of impairing the quality of life to the same extent or even more than severe organic gastrointestinal diseases. these disorders have a significant burden on the health care system. the aim of this study was to determine the prevale...

N-Substituted aromatic compounds can be metabolized in most species to N-acetylated derivatives that are themselves subject to further enzymatic transformations, including hydrolysis and N,O-acyltransfer. These proceses can either potentiate or ameliorate the biological responses to these N-substituted derivatives. Decreasing the levels of metabolites, such as arylhydroxylamines may, in some sy...

This paper proposes a new neocognitron that accepts incremental learning, without giving a severe damage to old memories or reducing learning speed. The new neocognitron uses a competitive learning, and the learning of all stages of the hierarchical network progresses simultaneously. To increase the learning speed, conventional neocognitrons of recent versions sacrificed the ability of incremen...