compound n2, n3, n7, n8, 1, 4, 5, 6, 9, 10-decaphenyltetradecahydrodipyrazino [2, 3-b: 2, 3-e] pyrazine-2, 3, 7, 8-tetraamine (4) was prepared by condensation of 1, 1′, 2, 2′-tetrakis (phenylamino) ethane (1d) and glyoxal in etoh or i-proh. also, reaction of 1d with glyoxal in equimolare in etoh resulted 5,6-bis (ethoxy)-n2, n3, 1, 4-tetraphenylhexahydro-2, 3-pyrazinediamine (5). the natures of...

Abstract This study aims to find out the way of synthesis, formulas, electronic spectra, magnetic properties, and infrared spectra formed from copper(II) with hydantoin. Copper(II)-hydantoin complex has been synthesized a mole ratio 1:2 metal ligand in methanol. The empirical formula estimated analysis copper content was Cu(hydantoin) 3 SO 4 (H 2 O) n (n = 3, or 5). Electrical conductivity show...

A set of 30 substituted 5,5'-diphenyl-2-thioxoimidazolidin-4-one (thiohydantoins) derivatives was synthesized, and their affinity for the human CB(1) cannabinoid receptor has been evaluated. These compounds are derived from the previously described cannabinoid ligands 5,5'-diphenylimidazolidine-2,4-dione (hydantoins). The replacement of the oxygen by a sulfur leads to an increase of the affinit...

BACKGROUND The general purpose of this study was to deduce the geometry of the bioactive face (pharmacophore) for the hydantoin class of anticonvulsants. METHODS Six hydantoin analogs, selected as probes of hydantoin structure, were synthesized. Nuclear magnetic resonance spectroscopy and molecular modelling calculations were used to determine the geometric relationship between the aromatic g...