?O: J#P5:@3H3@#@N35#K N5G@#TNKN@! NG N5(:G@NP#@:; &N@ON5 @O: GO:#HN5P T3$ #22H3$NJ#@N35 N5 @O: K#HP: "KG#GG:H 5*JT:H H:PNJ:/ S5 @ONG H:PNJ:< &ON=O NG 37 7*5;#J:5@#K NJ23H@#5=: @3 #G@H32O!GN=#K #==H:@N35 ;NGL @O:3H!< GO:#H NG @O: ;3JN5#5@ G3*H=: 37 :5:HP!< T*@ @O: N5G@#TNKN@! N@G:K7 H:.*NH:G @O: 2H:G:5=: 37 # &:#L:H (:H@N=#K J#P5:@N= 6:K;/ %NGGN2#@N(: :77:=@G #H: &:#L:H G@NKK T*@ 53@ 5:PKNPNTK:/...

PURPOSE To determine the identity of the transport process that is responsible for the uptake of N5-methyltetrahydrofolate, the predominant form of folate in blood, into cultured human retinal pigment epithelial cells. METHODS Human retinal pigment epithelial cells were cultured on an impermeable plastic support, and the characteristics of the uptake of radiolabeled N5-methyltetrahydrofolate ...

Using transferred cross-correlated relaxation and DFT calculations, the conformation of the relevant conformation of N5,N10-methylenetetrahydromethanopterin, a reaction intermediate bound to the 80 kD H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase is determined. The conformation of the intermediate differs from the free form in solution and makes the reaction mechanism plausible.

Flavins are central to the reactivity of a wide variety of enzymes and electron transport proteins. There is great interest in understanding the basis for the different reactivities displayed by flavins in different protein contexts. We propose solid-state nuclear magnetic resonance (SS-NMR) as a tool for directly observing reactive positions of the flavin ring and thereby obtaining information...

Solution. The prime factorization of 185 is 5*37. Given a group of order 185, Let n5 be the number of subgroups of order 5 and n37 the number of subgroups of order 37. Since subgroups of order 5 and 37 will be Sylow subgroups, by the Sylow Theorems n5 and n37 have to be 1 (mod 5) and 1 (mod 37), respectively and divide 37 and 5, respectively. Hence, n5 = n37 = 1 and the 5 and 37 Sylow subgroups...

First we will prove a small lemma. Lemma 1. Let P be a p-Sylow subgroup of G. Let N be a normal subgroup of G such that P ⊂ N . Then all p-Sylow subgroups are in N . Proof. Let P̃ be a p-Sylow subgroup that is not P . Then by the Sylow Theorems, we know that gPg−1 = P̃ for some g ∈ G. Since P ⊂ N , and N is normal, we know that gPg−1 ⊂ N and hence P̃ ⊂ N . Thus all p-Sylow subgroups are in N . Now...

Acinetobacter baumannii has emerged as a serious problematic pathogen due to the ever-increasing presence of antibiotic resistance, demonstrating a need for novel, broad-spectrum antimicrobial therapeutic options. Antimicrobial nanoemulsions are emulsified mixtures of detergent, oil, and water (droplet size, 100 to 800 nm) which have broad antimicrobial activity against bacteria, enveloped viru...

A novel variant of 6-deoxyerythronolide B synthase (DEBS) module 2 was constructed to explore the balance between protein-protein-mediated intermodular channeling and intrinsic substrate specificity within DEBS. This construct, termed (N3)Mod2+TE, was co-incubated with a complementary, donor form of the same module, (N5)Mod2(C2), as well as with a mutant of (N5)Mod2(C2) with an inactive ketosyn...