نتایج جستجو برای: naftopidil
تعداد نتایج: 104 فیلتر نتایج به سال:
Chiral drug naftopidil (NAF), a specific α1D-adrenoceptor (AR) antagonist for the treatment of benign prostatic hyperplasia, was used in racemic form for several decades. Our recent work declared that NAF enantiomers showed the same antagonistic effects on the α1D-AR, but the binding mechanism of these two stereochemical NAF isomers to the α1D receptor remained unclear. Herein, we reported the ...
Hypothesis / aims of study Alpha-1 blockers are the first option for the medical treatment of benign prostatic hyperplasia (BPH), and differ in their likelihood of causing abnormal ejaculation and sexual dysfunction, depending on their affinity of alpha-1 adrenoceptor subtypes. A new alpha-1 blocker, silodosin is 162 times more selective for alpha-1A than for alpha-1B, and is approximately 55 t...
We have originally synthesized the naftopidil analogue 1-[2-(2-methoxyphenylamino)ethylamino]-3-(naphthalene-1-yloxy)propan-2-ol (HUHS 1015) as a new anticancer drug. HUHS1015 induces cell death in a wide variety of human cancer cell lines originated from malignant pleural mesothelioma, lung cancer, hepatoma, gastric cancer, colorectal cancer, bladder cancer, prostate cancer, and renal cancer. ...
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