Currently, more than 90% of compounds identified are water insoluble and or poorly water soluble, which is a bottle neck in the development of many new drug candidates. These poorly soluble drug molecules are difficult to formulate using conventional approaches and are associated with numerous formulation‐related performance issues. Formulating these compounds using lipid‐based systems is one o...

In this study, goat fat (Capra hircus) and melon oil were extracted and used to formulate self-nanoemulsifying drug delivery systems (SNEDDS) based on either goat fat alone or its admixture with melon oil by employing escalating ratios of oil(s), surfactant blend (1 : 1 Tween 60 and Tween 80), and cosurfactant (Span 85), with or without carbosil, a glidant, for the delivery of indomethacin. The...

The current study was aimed to investigate the potential of solid self-nanoemulsifying drug delivery system (SSNEDDS) composed of Capmul MCM C8 (oil), Cremophor RH40 (surfactant) and transcutol P (co-surfactant) in improving the dissolution and oral bioavailability of Nateglinide (NTG). Liquid self-nanoemulsifying drug delivery systems (L-SNEDDS) were developed by using rational blends of compo...