The reaction of 3-aminopyrazole (1) with 1,2-naphthoquinone-4-sulfonic acid sodium salt (2) was studied in different aqueous media. The novel pyrazolylnaphthoquinones synthesized were physical and spectroscopically characterized, including 2D NMR spectroscopy (HETCOR). The possible reaction mechanism is proposed. Introduction Quinones and naphthoquinones are widely distributed in nature and pla...

Apatone™, a combination of menadione (2-methyl-1,4-naphthoquinone, VK3) and ascorbic acid (vitamin C, VC) is a new strategy for cancer treatment. Part of its effect on tumor cells is related to the cellular pro-oxidative imbalance provoked by the generation of hydrogen peroxide (H2O2) through naphthoquinone redox cycling. In this study, we attempted to find new naphthoquinone derivatives that w...

The synthesis of a naphthoquinone amino acid and its electrochemical characterization in a peptide is presented.

Submit Manuscript | http://medcraveonline.com Abbreviations: GAE: Gallic Acid Equivalent; TAE: Tannic Acid Equivalent; QE: Quercetin Equivalent; AAE: Ascorbic Acid Equivalent; CN: Cyanidin 3-glucoside; ABTS: 2, 2-azinobis (3-ethylbenzothiazoline-6-sulphonic acid); DPPH: 2, 2-diphenyl1-picryhydrazyl; FRAP: Ferric Reducing Antioxidant Power; TPTZ: 2,4, 6-tri-2-pyridyl-1,3,5-triazin; FW: Fresh Weight

Immunological studies have shown an increased lymphocyte reactivity in patients with early stage bladder cancer and individuals with pre-stage T1 exposed to bladder carcinogens (2-naphthylamine and industrial 1-naphthylamine containing 4-8% 2-naphthylamine) before 1952-that is, those at high risk of developing bladder cancer. Because of the close chemical similarity of Tobias acid (2-naphthylam...