BACKGROUND: The nail involvement in psoriasis is related to psoriatic arthritis and may represent a predictor of the disease. OBJECTIVES: To analyze, through nail clipping, clinically normal and dystrophic nails of patients with cutaneous psoriasis and psoriatic arthritis. METHODS: This is a cross-sectional multicenter study, conducted between August 2011 and March 2012. Patients were divid...

Background / Objectives:Dermoscopy is a non-invasive technique that has been recognized recently as an effective tool in the diagnosis of nail diseases, including psoriasis. The aim this study was to clarify specific dermoscopic features psoriasis and identify those are correlated with disease severity. Methods: We conducted prospective over 18 months. Fifty patients followed for involvement we...

BACKGROUND: The main vector of psoriasis therapy is suppression proliferative activity keratinocytes, normalization their differentiation, neutralization immune inflammation in the dermis and cytokine balance.
 AIM: study was to efficacy tolerability an IL-17A inhibitor (secukinumab) as monotherapy combination with methotrexate patients moderate severe vulgaris.
 MATERIALS AND METHODS...

AChineseHerb, IndigoNaturalis, Extracted in Oil (Lindioil) Used Topically to Treat Psoriatic Nails: A Randomized Clinical Trial Indigo naturalis, a Chinese herb, has been used for decades.1 Olive oil was used to remove the blue component within indigo naturalis to yield a purple-red product to treat skin and nail psoriasis without obvious staining.2,3 This trial compared indigo naturalis extrac...

Background. Evaluation of the severity pathological angiogenesis in patients with psoriasis can be considered as a promising direction for monitoring activity disease and effectiveness systemic therapy.
 Aims. interconnections between indicators skin nail bed clinical characteristics course therapeutic response to use methotrexate by comprehensive study morphometric data dynamics videoderm...

To the Editor: Psoriasis affects nails in approximately 15% to 50% of patients, whereas isolated involvement is observed 5% 10% patients.1Dogra A. Arora A.K. Nail psoriasis: journey so far.Indian J Dermatol. 2014; 59: 319-333Crossref PubMed Scopus (46) Google Scholar,2Grover C. Daulatabad D. Singal Role nail bed methotrexate injections conventional drug via an unconventional route.Clin Exp 2017...

BACKGROUND In the phase III double-blind Efficacy and Safety Trial Evaluating the Effects of Apremilast in Psoriasis (ESTEEM) 1 and 2, apremilast, an oral phosphodiesterase 4 inhibitor, demonstrated efficacy in moderate to severe psoriasis. OBJECTIVE We sought to evaluate efficacy of apremilast in nail/scalp psoriasis in ESTEEM 1 and 2. METHODS A total of 1255 patients were randomized (2:1)...

BACKGROUND As psoriatic disease (PD) is a condition characterized by the combination of inflammatory skin (psoriasis) and osteo-articular manifestations (psoriatic arthritis), its treatment should cover both its clinical components. OBJECTIVE The objective of this study was to propose a flexible framework for the use of biological agents in PD. METHODS The proposal was drawn up by a group o...

To identify patients that benefit most from ixekizumab (IXE), unsupervised machine learning applied to Psoriasis Area and Severity Index (PASI) improvement was used define IXE-response clusters in with psoriasis. Using these identified based on PASI, responses challenging body areas (CBA) as well Static Physicians Global Assessment (sPGA) were assessed through 52 weeks. These analyses included ...

Background The prevalence of nail disease in patients with psoriatic arthritis (PsA) ranges between 41% and 93% [1] . Psoriatic is intimately linked to adjacent distal interphalangeal joint (DIP) disease, it important ascertain whether DIP-nail complex behaves differently under different biological therapies. Objectives aim this analysis was comparatively assess the effect ixekizumab (IXE) adal...