BACKGROUND Nasal inflammatory disorders such as chronic rhinosinusitis and nasal polyp are among the most prevalent complications with high socioeconomic costs. Vascular Endothelial Growth Factor (VEGF) plays a key role in angiogenesis and cell proliferation. In the present study the effect of VEGF on the development and prognosis of chronic rhinosinusitis and nasal polyp was investigated. ME...

Eustachian tube maintains middle ear pressure equal to that of atmospheric pressure and its functions is deranged due to various nasal, nasopharyngeal and palatal causes. Nasal polypi cause post nasal drip which is considered to cause Eustachian tube dysfunction. The present cross sectional study comprises of a total of 39 patients of Antrochoanal polyp with the aim to see the effect of antroch...

Fibroepithelial polyp (FEP) is a benign tumor of mesodermal origin, which mostly found on the skin. FEPs in upper respiratory system are reported originating from oropharynx and larynx, rarely nasal cavity. A 57-year-old female presented with polyp-like lesion right septal mucosa adjacent to mucocutaneous junction. The mass was surgically removed, diagnosis FEP made based histopathological revi...

Sushruta has mentioned 31 Rogas of Nasa in which Nasarsha is described. can be correlated to Nasal polyp. It a benign mass inflamed mucosal tissue wall. Some common symptoms polyp congestion, sneezing, headache and runny nose. The prevalence rate polyps approximately 1% 4% general population. Certain medications surgeries are used treat Polyp modern science with major reccurence rate. In Ayurve...

Background and Objective: Nasal polyp is the most common benign mass of the nasal cavity and it is originated from nasal cavity or sinuses. Cytokeratins (CK) are intermediate filament proteins that provide mechanical support in epithelial cells. The purpose of this study was to compare the expression of cytokeratin 7 in epithelium of nasal polyps and nasal mucosa in chronic rhinosinusitis. Mate...

Most of the nasal polyps arise from the lateral walls of the nasal cavity. Nasal polyps originating from the nasal septum with choanal extension are extremely rare. We report a case of large choanal polyp that arised from the posterosuperior aspect of the nasal septum, and extended down to the oropharynx. A 52-year-old woman presented with a two-year history of progressive nasal obstruction and...

BACKGROUND Influenza viruses bind and infect respiratory epithelial cells through sialic acid on cell surface. Differential preference to sialic acid types contributes to host- and tissue-tropism of avian and seasonal influenza viruses. Although the highly pathogenic avian influenza virus H5N1 can infect and cause severe diseases in humans, it is not efficient in infecting human upper respirato...

Aspirin-induced asthma is often accompanied by nasal polyps, in which tissue eosinophils are abundant and activated. However, the mechanism of eosinophil infiltration remains unknown. We encountered two aspirin-induced asthma patients with nasal polyps and investigated eosinophil infiltration into nasal polyp tissue. Eosinophil chemotactic activity of extracts from the nasal polyp was elevated ...

BACKGROUND : Accumulation of T cells and immature dendritic cells (DCs) is one of the characteristic features of nasal polyps. However, the question remains why these cells accumulate in nasal polyp tissue. Macrophage inflammatory protein-3α; (MIP-3α;/CCL20) is a chemokine involved in the migration of T cells and immature DCs into inflammatory tissue sites. Fibroblasts are a rich source of cyto...

Tissue eosinophilia is a characteristic feature of a number of inflammatory diseases including asthma and nasal polyposis. Eosinophil migration into tissues is controlled in part by interactions between eosinophil adhesion receptors and counter-structures on the vascular endothelium. To determine the receptors used by eosinophils to adhere to vascular endothelium in allergic inflammation we hav...