BACKGROUND Nasal polyposis is characterized by impaired regulation of nasal tissue growth and is associated with chronic inflammation, sinus infections, and low levels of nitric oxide (NO). Based on its critical role in mediating cell growth and antimicrobial function, decrease of NO levels has been implicated in the pathogenesis of nasal polyposis. OBJECTIVE We sought to evaluate mechanisms ...

BACKGROUND Allergic rhinitis and nasal polyposis are common nasal diseases, but the available treatment modalities have only limited success. OBJECTIVE To assess the therapeutic effect of low-energy narrow-band red light phototherapy on nasal clinical symptoms of allergic rhinitis and nasal polyposis. METHODS In a double-blind randomized prospective study, 50 patients with allergic rhinitis...

BACKGROUND Fungi, especially Aspergillus flavus, can cause chronic rhinosinusitis with nasal polyposis and modulate host innate immune components. The objective of this study was to examine the serum levels of T helper (Th) cell subset Th1, Th2, and Th17 cytokines and total IgE in patients having chronic rhinosinusitis with nasal polyposis and Aspergillus flavus infection. METHODS A case-cont...

The aim of this prospective study was to evaluate whether cytokine levels in nasal secretions may be clinical parameters of severity of nasal polyposis. Forty nasal polyp patients (20 asthmatic and 20 nonasthmatic) requiring surgical treatment were included. Nasal secretion samples were collected from nasal cavities of all 40 subjects. The levels of T-helper type 1 (Th1) proinflammatory cytokin...

OBJECTIVES/HYPOTHESIS Topical steroid therapy is an important strategy in the management of chronic rhinosinusitis (CRS) with nasal polyposis. The objective of this study was to determine the impact of topical steroid therapy on nasal symptoms in patients with nasal polyposis. STUDY DESIGN Systematic review with meta-analysis using standardized methodology. METHODS Study inclusion criteria ...

OBJECTIVES/HYPOTHESIS The aim of this study is to determine the role of free radicals and antioxidants in nasal polyps. STUDY DESIGN Prospective, randomized, controlled study. METHODS Thirty-one patients with nasal polyposis and a control group consisting of 19 patients with septal deviation and lower turbinate hypertrophy were included in the study. Levels of the antioxidants retinol, beta...

background and objectives: nasal polyposis is a diseases resulting from complex pathogenetic mechanisms. some studies showed that tgfβ1 had significant role in this pathogenesis. in this study, we investigated the roe of cytokines and mediators in polyp development. material and methods: in this case- control study, healthy nasal mucosal samples were obtained from 24 people undergoing septoplas...

INTRODUCTION To evaluate the most sensitive symptom to predict early recurrence of nasal polyposis. Prospective longitudinal cohort study. Tertiary university referral center with accredited otorhinolaryngology residency programs. MATERIALS AND METHODS In this prospective study, we evaluated 62 patients with diffuse nasal polyposis. All patients underwent functional endoscopic sinus surgery. ...

Nasal polyposis represents as a chronic hyperplastic sinusitis associated with chronic inflammation. In present retrospective study, we aimed to compare the Mean Platelet Volume (MPV), Red Cell Distribution Width (RDW) and Neutrophil to Lymphocyte Ratio (NLR) values of patients with nasal polyposis to those in healthy subjects. We included 35 nasal polyp patients and 45 healthy subjects into th...