نتایج جستجو برای: nec
تعداد نتایج: 3186 فیلتر نتایج به سال:
INTRODUCTION Necrotizing enterocolitis (NEC) affects 5-10% of infants born weighing less than 1500 g. Most models of NEC recapitulate late-stage disease with gut necrosis and elevated inflammatory mediators. Evaluation of NEC at earlier, less lethal stages of disease will allow investigation of initial disease triggers and may advance our understanding of temporal relationships between factors ...
BACKGROUND Eosinophils infiltrate intestinal tissue during necrotizing enterocolitis (NEC) and adult bowel diseases. We theorized that epithelial damage causes eosinophilic activation and recruitment at NEC onset. OBJECTIVE We studied the relationship between persistent blood eosinophilia and medical or surgical complications during NEC. METHODS NEC cases and controls at MU Children's Hospi...
OBJECTIVES To examine the variation in the incidence and to identify the timing of the presentation of necrotizing enterocolitis (NEC) in a cohort of preterm infants within the Canadian Neonatal Network (CNN). METHODS This was a population-based cohort of 16 669 infants with gestational age (GA) <33 weeks, admitted to 25 NICUs participating in the CNN between January 1, 2003, and December 31(...
BACKGROUND Intestinal stricture is an important complication of necrotising enterocolitis (NEC). We aimed to describe clinical profile and identify the risk factors for post-NEC intestinal strictures. METHOD A retrospective study of infants with NEC over 10 year period. RESULTS Of the 61 infants with NEC, 18 (29.5%) developed intestinal strictures. Leucocytosis and longer length of bowel re...
BACKGROUND Necrotizing enterocolitis (NEC) is a devastating intestinal disease that afflicts 10% of extremely preterm infants. The contribution of early intestinal colonization to NEC onset is not understood, and predictive biomarkers to guide prevention are lacking. We analyzed banked stool and urine samples collected prior to disease onset from infants <29 weeks gestational age, including 11 ...
مقدمه: انتروکولیت نکروزان (nec) از علل شایع مرگ و میر نوزادان پره ماچور است. پره ماچوریتی و کلونیزاسیون غیرطبیعی باکتری ها نقش اصلی را در ایجاد nec بازی می کند. مطالعات نشان داده است که تجویز پروبیوتیک ها خطر nec و مرگ و میر را در نوزادان نارس کاهش می دهد. این مطالعه برای تعیین تأثیر پروبیوتیک در پیشگیری از انتروکولیت نوزادان نارس با وزن 1000 تا 2500 گرم با یک داروی ایرانی که مطالعه مشابهی بر ر...
Necrotizing enterocolitis (NEC) is an inflammatory disease of the newborn bowel, primarily affecting premature infants. Early intestinal colonization has been implicated in the pathogenesis of NEC. The objective of this prospective case-control study was to evaluate differences in the intestinal microbiota between infants who developed NEC and unaffected controls prior to disease onset. We cond...
Necrotizing enterocolitis (NEC) is a complication of prematurity. The etiology is unknown, but is related to enteral feeding, ischemia, infection, and inflammation. Reactive oxygen species production, most notably superoxide, increases in NEC. NADPH oxidase (NOX) generates superoxide, but its activity in NEC remains unknown. We hypothesize that NOX-derived superoxide production increases in NEC...
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