Seven monoclonal antibodies (mAb) specific for defined discontinuous and continuous epitopes on glycoprotein D of herpes simplex virus type 1 (HSV-1) were surveyed for their capacity to protect against virus-induced corneal disease in a murine ocular infection model. A known amount of purified mAb was transferred passively to BALB/c mice 24 hr after topical infection with HSV-1 on their scarifi...

PURPOSE To investigate the effect of Fas and Fas ligand (FasL) deficiency on the development of herpes stromal keratitis and on the von Szily model of herpes retinitis in C57BL/6 mice, which are ordinarily resistant to development of both of these herpetic diseases. METHODS Anterior chamber inoculation of the right eye of each mouse with various titers of HSV-1 (KOS strain) was performed. Bot...

Thirty patients with bilateral herpetic keratitis were evaluated, 40% of whom were atopic. Stromal keratitis occurred in 40% of the eyes and recurrent ulceration in 68%. Four patients (5 eyes) developed secondary microbial keratitis. Visual acuity decreased to 6/60 or less because of corneal opacification in 17% of the eyes.

<b>Purpose:</b> of review: To discuss peripheral ulcerative keratitis, with a focus on the evaluation and management associated systemic diseases. <b>Recent findings:</b> Peripheral keratitis (PUK) is sight-threatening condition that often defined by presence crescent-shaped area corneal thinning, an epithelial defect, inflammatory infiltrate. It highly rheumatoid arthri...

Acanthamoebic keratitis, a potentially devastating infection usually associated with contact lens wear, has been recognized with increasing frequency in recent years. Once the Acanthamoeba organisms gain access to the human cornea, it is not clear which constituents of the corneal milieu provide a substrate for their growth. The growth of Acanthamoeba polyphaga was investigated on cultured mono...

BACKGROUND Corneal perforation is an uncommon complication associated with keratoconus. The first cases of infectious keratitis and corneal perforation associated with corneal hydrops and contact lens wear are reported in two keratoconus patients. METHODS A retrospective chart review and histopathological examination were carried out. RESULTS Both patients progressed to corneal perforation ...

81 Topical cyclosporine as an alternative treatment for herpetic interstitial keratitis Ciclosporina tópica como alternativa eficaz en el tratamiento de las queratitis intersticiales herpéticas Dear Sir, Infection due to herpes simplex virus (HSV), also known as human herpes virus (HHV), continues to be the most frequent cause of corneal blindness in developed countries, where the prevalence ra...

The importance of specific immunity, especially cell-mediated, in resistance to herpes simplex disease is well documented, and animal experiments show that immune responses to previous herpetic infection can give considerable protection against reinfection in epithelial keratitis. Since susceptibility to stromal herpetic keratitis is probably determined in part by the extent of virus proliferat...

Experimental Acanthamoeba keratitis was induced in Wistar rats by intrastromal inoculation of Acanthamoeba polyphaga cysts. Keratitis developed in all corneas injected and was characterised by a diffuse granular opacity. The animals were examined for 70 days and a gradual reduction of keratitis was observed. Pathological sections showed liquefactive stromal necrosis and Acanthamoeba localised i...

Due to impaired defensive mechanisms caused by injuries or little epithelial defects , different types of pathogens or environmental influences might induce corneal inflammation (keratitis). The form of corneal inflammation called superficial keratitis involves just the corneal surface (epithelium). If the inflammation involves corneal stroma it is called stromal or interstitial keratitis. Kera...