platelet activation and adhesion to the site of vascular injury is a dynamic process comprising reversible and irreversible phases. platelet adhesion typically occurs in a multi-step process similar to the selectin/integrin-mediated adhesion of neutrophils. this phenomenon is highly regulated and influenced by the cross-talk between platelets and injured endothelium. this cross-talk involves a ...

The expression of neural cell adhesion molecules and myelin-specific molecules is precisely regulated according to cell type and developmental age. We investigated whether different isoforms of these molecules change during development of oligodendrocytes. Immature oligodendrocytes cultured from embryonic day 18 rat cerebrum were distinguished into early stage and late stage by morphological an...

Cadherins are Ca(2+)-dependent cell-cell adhesion molecules that play critical roles in animal morphogenesis. Various cadherin-related molecules have also been identified, which show diverse functions, not only for the regulation of cell adhesion but also for that of cell proliferation and planar cell polarity. During the past decade, understanding of the roles of these molecules in the nervous...

Both carcinoembryonic antigen (CEA) and neural cell adhesion molecule (NCAM) belong to the immunoglobulin supergene family and have been demonstrated to function as homotypic Ca(++)-independent intercellular adhesion molecules. CEA and NCAM cannot associate heterotypically indicating that they have different binding specificities. To define the domains of CEA involved in homotypic interaction, ...

endothelial dysfunction is thought to be a central pathogenic feature in preeclampsia on the basis of elevated adhesion molecules. soluble forms of these molecules can be detected in plasma, and their concentrations are thought to reflect the degree of activation of a particular cell type. the aim of the present study was to compare the levels of soluble vascular cell adhesion molecule-1 (svcam...

Cell adhesion molecules of the immunoglobulin superfamily (IgSF) including the neural cell adhesion molecule (NCAM) and members of the L1 family of neuronal cell adhesion molecules play important functions in the developing nervous system by regulating formation, growth and branching of neurites, and establishment of the synaptic contacts between neurons. In the mature brain, members of IgSF re...

neural cell adhesion molecules (ncams) are known to influence memory by affecting neural cell-cell and cell-extracellular matrix junctions. this study investigated the possible role of camp pathway in the expression of hippocampal ncam and its polysialylated derivative (psa-ncam). the following pharmacological tools were employed for manipulation of camp pathway: a) forskolin; the activator of ...

Both neural cell adhesion molecules (N-CAM) and tenascin (cytotactin) are important in embryonic morphogenesis but their expression is reduced greatly in adults. This study examined whether they are induced during wound healing. The spatial and temporal expression patterns of these two and other adhesion molecules in the healing of skin, cartilage, and tendon were compared. Neural cell adhesion...

BACKGROUND Polysialic acid (polySia) is a carbohydrate modification of the neural cell adhesion molecule (NCAM), which is implicated in neural differentiation and plays an important role in tumor development and metastasis. Polysialylation of NCAM is mediated by two Golgi-resident polysialyltransferases (polyST) ST8SiaII and ST8SiaIV. Intracellular antibodies (intrabodies; IB) expressed inside ...