We attempted transplantation of adult neural stem cells (ANSCs) inside an autologous venous graft following surgical transsection of nervis cruralis with 30 mm long gap in adult pig. The transplanted cell suspension was a primary culture of neurospheres from adult pig subventricular zone (SVZ) which had been labeled in vitro with BrdU or lentivirally transferred fluorescent protein. Lesion-indu...

Grapensparr, L. 2017. Auxiliary Cells for the Vascularization and Function of Endogenous and Transplanted Islets of Langerhans. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1348. 56 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-513-0023-8. Type 1 diabetes develops through the progressive destruction of the insulin-producing betacells. Regenera...

Evidence for the survival, growth and function of grafted neural tissues in the adult mammalian brain is reviewed. In addition to considering the viability of grafts in the different model systems that have been investigated, consideration is given to alternative mechanisms by which the grafts might exert a functional influence over the host brain and the host animal's behaviour: (a) acute infl...

Neurons destined to form several precerebellar nuclei are generated in the dorsal neuroepithelium (rhombic lip) of caudal hindbrain. They form two ventrally directed migratory streams, which behave differently. While neurons in the superficial migration migrate in a subpial position and cross the midline to settle into the contralateral hindbrain, neurons in the olivary migration travel deeper ...

Over the last 30 years, numerous allogeneic and xenogeneic cell grafts have been transplanted into the central nervous system (CNS) of mice and men in an attempt to cure neurological diseases. In the early studies, human or porcine embryonic neural cells were grafted in the striatum of animals or patients in an attempt to replace lost neurons. Although the immune-privileged status of the brain ...

it is difficult to reconstruct an alar defect with cartilage involvement. here in the authors report a case of traumatic alar loss during childhood in which an alar reconstruction was carried out with a composite auricular graft put over the pedicle buccal flap which was rotated and passed through the intraoral side. the lining skin and auricular cartilage for the flap was obtained from the aur...

BACKGROUND Data available on the immunomodulatory properties of neural stem/precursor cells (NPC) support their possible use as modulators for immune-mediated process. The aim of this study was to define whether NPC administered in combination with pancreatic islets prevents rejection in a fully mismatched allograft model. METHODOLOGY/PRINCIPAL FINDING Diabetic Balb/c mice were co-transplante...

A 29-year-old soldier was injured when a collapsible side of an army truck fell on his left upper arm creating lesion to the brachial artery with a defect in the artery of about 10 cm in length. Injury to one brachial vein, of the same length, was also sustained without bone or neural injury. Intraoperative Doppler ultrasonography was performed. A reverse autologous saphenous vein interposition...

1. Abstract The optimization of graft and anastomotic configurations with regard to blood dynamics is the major target of this study. A developed multi-objective genetic algorithm is considered in order to reach optimal graft geometries for idealized arterial bypass systems of fully occluded host arteries. An artificial neural network simulating hemodynamic specific conditions is introduced in ...