OBJECTIVE Recent guidelines reveal that allergic rhinitis impairs quality of life. Neuropeptides play a central role in allergy-related nasal inflammation. The objective of this study was to analyze the release of neuropeptides (substance P, neurokinin A, and vasoactive intestinal peptide) in nasal lavage and their modification by intranasal fluticasone propionate as an established therapy in p...

Neuropeptides such as vasoactive intestinal peptide (VIP) and calcitonin gene-related peptide (CGRP) are present in nerve fibers of bone tissues and have been suggested to potentially regulate bone remodeling. Oscillatory fluid flow (OFF)-induced shear stress is a potent signal in mechanotransduction that is capable of regulating both anabolic and catabolic bone remodeling. However, the interac...

In prior studies, we evidenced the presence in fish hypothalamus of different systems sensing changes leucine levels to relate them food intake control. To assess whether or not those effects are due a direct action leucine, evaluated present vitro study if rainbow trout (Oncorhynchus mykiss) respond way comparable that observed vivo. Thus, incubated with increased concentrations (1, 5 and 25 m...

Pedal peptide (PP) and orcokinin (OK) are related neuropeptides that were discovered in protostomian invertebrates (mollusks, arthropods). However, analysis of genome/transcriptome sequence data has revealed that PP/OK-type neuropeptides also occur in a deuterostomian phylum-the echinoderms. Furthermore, a PP/OK-type neuropeptide (starfish myorelaxant peptide, SMP) was recently identified as a ...

Neuropeptides are mainly secreted from the human central and peripheral nervous systems. bind to its cognate rhodopsin-like G-protein coupled receptor (GPCR) perform various physiological functions. Conventional cancer treatments in clinical practice still present many drawbacks due lack of selectivity toward target cell, drug-resistance, side-effects, thus pushing for development new therapeut...

Neuropeptides play critical roles in synaptic signaling in all nervous systems. Unlike classical neurotransmitters, peptidergic neurotransmitters are encoded as preproproteins that are posttranslationally processed to yield bioactive neuropeptides. To identify novel peptidergic neurotransmitters, the Caenorhabditis elegans genome was searched for predicted proteins with the structural hallmarks...