Abstract Respiratory Syncytial Virus (RSV) is a leading cause of morbidity and mortality in children, due part to their distinct immune system, characterized by impaired induction T-helper 1 (Th1)□immunity. Here we describe cationic adjuvant formulation (CAF)-08, liposomal vaccine tailored induce Th1 immunity early life via synergistic engagement Toll-like Receptor 7/8 the C-type lectin recepto...

Pertussis continues to be a significant cause of morbidity and mortality in infants and young children worldwide. Methods to control the disease are based on vaccination with either whole-cell or acellular vaccines or treatment with antibiotics. However, despite worldwide vaccination infants are still at the highest risk for the disease. Here we used our newly developed newborn-piglet model to ...

Maternal antibodies to the Coxsackie viruses (C virus) are conveyed to newborn mice through the colostrum and milk. of vaccinated mothers. No evidence for or against placental transmission of immunity was obtained. The immunity conferred on the young is type-specific. Immunity may be conferred to infants born of non-immune mice by allowing a suckling period of 24 to 48 hours with an immune moth...

Preterm infants are especially susceptible to late-onset sepsis that is often due to Gram-positive bacterial infections resulting in substantial morbidity and mortality. Herein, we will describe neonatal innate immunity to Staphylococcus spp. comparing differences between preterm and full-term newborns with adults. Newborn innate immunity is distinct demonstrating diminished skin integrity, imp...

Despite significant progress in reducing the burden of mortality in children under the age of five, reducing mortality in newborns remains a major challenge. Infection plays a significant role in infant deaths and interventions such as early vaccination or antenatal immunization could make a significant contribution to prevention of such deaths. In the last few years, we have gained new insight...

Primary immune deficiency diseases (PIDDs) are a group of severe genetically determined caused by disorder the immunity links: humoral and cell-mediated links, phagocytosis, complement system. PIDDs characterized atypical recurrent infections, as well autoimmune oncological processes. In case clinical symptoms, skin manifestations in allow to suspect presence congenital disorders immunity. Ther...

The authors found that the density of colostrum in cows with a homozygous genotype for B allele kappa-casein gene was higher compared to A and had greater amount immunoglobulins by 29.5 mg/l, respectively. formation high colostral immunity calves obtained from mothers genotypes AB BB prevented occurrence diseases gastrointestinal tract, AA reduced colostrum, it led development diarrhea 12% newb...

In mammals, passive immunity is transferred from mother to offspring by transplacental passage or by intestinal absorption . The rabbit receives antibodies exclusively across the placenta, whereas intestinal absorption is the principal source of antibodies for the newborn pig. In the rat, passive immunity is transferred by both pathways . The role of the jejunal absorptive cells was investigate...

Newborn (neonatal) is the first 28 days of human life. At this time there a process adjusting baby's body system from intra-uterine life to extra-uterine This period that needs extra attention and care because when mortality rate highest. The culture Toba Batak tribe has certain traditions have been applied generation until now in terms caring for newborns. study uses qualitative phenomenologic...