Fe3O4 nanoparticles were synthesized and functionalized with (3-aminopropyl) trimethoxysilane (APTMS) chitosan, forming Fe3O4-NH2 Fe3O4-NH2-chitosan nanoparticles. The by a co-precipitation method functionalization was performed in further stages. characterized X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), zeta potential, transmission electron microscopy (TEM). result...

Multiple myeloma is a slowly proliferating B-cell malignancy that accumulates apoptosis-resistant and replication-quiescent cell populations, posing a challenge for current chemotherapeutics that target rapidly replicating cells. Multiple myeloma remains an incurable disease in need of new therapeutic approaches. The purine nucleoside analogue, 8-amino-adenosine (8-NH2-Ado), exhibits potent act...

This work reports the solvothermal synthesis of a titanium-based metal organic framework (NH2-MIL-125(Ti)) and further deposition palladium, platinum silver nanoparticles on its framework, with aim to obtain visible light-driven photocatalysts. The structure NH2-MIL-125 was not affected by incorporation nanoparticles, while textural properties changed depending used. All M/NH2-MIL-125 (M = Pd, ...

Previous studies suggest that the conjugation of ubiquitin to NH2 groups of proteins is required for protein breakdown. We now show that the selective modification of NH2-terminal alpha-NH2 groups of globin and lysozyme prevents their degradation by the ubiquitin proteolytic system from reticulocytes. The conjugation by ubiquitin of epsilon-NH2 groups of lysine residues, usually seen in multipl...

Protease-activated receptors (PARs) 1 and 2 are expressed in capsaicin-sensitive sensory neurons, being anti- and pro-nociceptive, respectively. Given the possible cross talk between PAR-2 and capsaicin receptors, we investigated if PAR-2 activation could facilitate capsaicin-evoked visceral pain and referred hyperalgesia in the mouse and also examined the effect of PAR-1 activation in this mod...

The influence of cation-π interactions on the electrochemical properties of copper(II) complexes with synthesized pentapeptide C-terminal fragment of Atrial Natriuretic Factor (ANF) hormone was studied in this work. Molecular modeling performed for Cu(II)-NSFRY-NH2 complex indicated that the cation-π interactions between Tyr and Cu(II), and also between Phe-Arg led to specific conformation defi...

To find mammalian analogues of exendin-4, a peptide from Helodermatidae venoms that interacts with newly discovered exendin receptors on dispersed acini from guinea pig pancreas, we examined the actions of recent additions to the vasoactive intestinal peptide/secretin/glucagon family of regulatory peptides. In every respect tested, the truncated form of glucagon-like peptide-1, GLP-1(7-36)NH2, ...

A full-dimensional quantum dynamical study for the bimolecular reactions of hydrogen molecules with amino radicals different isotopologues is reported. The nonreactive radical described by two Radau vectors that are very close to valence bond coordinates. Potential-optimized discrete variable representation basis used vibrational coordinates radical. Starting from reaction H2 + NH2, we isotope ...

The effects of PAR2-activating PAR2-activating peptides, SLIGRL (SL)-NH2, and trans-cinnamoyl-LIGRLO (tc)-NH2 were compared with the action of trypsin, thrombin, and the PAR1 selective-activating peptide: Ala-parafluoroPhe-Arg-cyclohexylAla-Citrulline-Tyr (Cit)-NH2 for stimulating intestinal ion transport. These agonists were added to the serosa of stripped rat jejunum segments mounted in Ussin...