In spite of the fact that smoking is the main cause of obstetric morbidity and mortality, 20% of North American women smoke during pregnancy. In Spain, this figure is as high as 30% to 35%. Treating smoking addiction in these patients should be the first and most important therapeutic measure undertaken by health professionals responsible for the care of pregnant women. All experts recommend th...

Cigarette smoking is a major modifiable cause of adverse pregnancy outcomes. Nicotine-replacement therapy (NRT) is recommended in guidelines, but its efficacy and safety during pregnancy is uncertain. This multicentre double-blind trial recruited 1050 pregnant participants who were in their 12–24 weeks’ gestation periods. All of them smoked ≥5 cigarettes per day (median 20). Participants were r...

cYTISINE VS NIcOTINE FOr SmOkING cESSaTION This randomized, pragmatic, open-labeled trial conducted in New Zealand compared cytisine against nicotine replacement therapy in a sample of 1310 adult daily smokers who had called the national quitline for support. Cytisine is a plant-based alkaloid similar to varenicline and acts on the same nicotinic acetylcholine receptors. Four previous systemati...

abstract  introduction: smoking is an important risk factor of coronary artery disease. nicotine replacement therapy (nrt) for smoking cessation should be considered, especially in coronary patients. methods: twenty-four healthy smokers, smoking an average of 20 cigarettes a day for 15 years and with moderate cigarette dependence (according to the fagershtrum questionnaire score) were randomly ...

Behavioral couples therapy (BCT) has been found to improve long-term abstinence rates in alcohol- and substance-dependent populations but has not been tested for smoking cessation. This pilot study examined the feasibility and acceptability of BCT for smoking-discordant couples. Forty-nine smokers (smoking >10 cigarettes/day) with nonsmoking partners were randomized to receive a couples social ...

OBJECTIVE To test the efficacy of nortriptyline plus nicotine replacement therapy compared with placebo plus nicotine replacement therapy for smoking cessation. DESIGN Pragmatic randomised controlled trial. SETTING National Health Service stop smoking service clinics. PARTICIPANTS 901 people trying to stop smoking. INTERVENTIONS Participants chose their nicotine replacement product, inc...

OBJECTIVE To assess the efficacy of nicotine replacement therapy in helping people to stop smoking. DESIGN Analysis of the results of 28 randomised trials of nicotine 2 mg chewing gum, six trials of nicotine 4 mg chewing gum, and six trials of nicotine transdermal patch. SUBJECTS AND SETTING Subjects were self referred (responding to advertisements or attending anti-smoking clinics) in 20 t...