Niosomes as a vesicular system are well documented for delivering drugs, in controlled manner to enhance bioavailability and get better therapeutic effect over a longer period of time. Celecoxib is a NSAID, selective COX-2 inhibitor, which is used for treatment of rheumatoid arthritis, osteoarthritis and acute pain. The present study dealt with the preparation and characterization of celecoxib ...

Niosomes are considered as novel nano-carrier in the drug delivery systems. These much more stable than other nano-carriers like liposomes and nanoparticles. It is an example for targeted control release of medication. The entrapped into lipid core so that it prevents from leaching. Here will be only to desired cell/tissue not non-targeted cells. By giving this formulation we can thereby reduce...

The present study was conducted to investigate the performance of different size reduction techniques including probe sonication, extrusion, and high pressure homogenization for nanosizing of niosomes. Also, the effects of cholesterol content and surfactant type on the size and poly dispersity index (PDI) of the formulations were evaluated. Various niosomal formulations composed of Brij 72, Spa...

Design and development of novel drug delivery system (NDDS) has two prerequisites. First, it should deliver the drug in accordance with a predetermined rate and second it should release therapeutically effective amount of drug at the site of action. Conventional dosage forms are unable to meet these requisites. Niosomes are essentially non-ionic surfactant-based multilamellar or unilamellar ves...

The aim of the present work was to prepare and evaluate sublingual fast dissolving films containing metoprolol tartrate-loaded niosomes. Niosomes were utilized to allow for prolonged release of the drug, whereas the films were used to increase the drug's bioavailability via the sublingual route. Niosomes were prepared using span 60 and cholesterol at different drug to surfactant ratios. The nio...

Purpose: To develop and evaluation ascorbyl palmitate niosomes in order to achieve a transdermal and/or systemic nanocarier of doxycycline. Methods: Vesicles were formed from ascorbyl palmitate in combination with cholesterol and a negatively charged lipid, dicetyl phosphate. Niosomes were prepared by film hydration method followed by sonication in which aqueous doxycycline solution (in phospha...

Niosomes are a novel drug delivery system, in which the medication is encapsulated vesicle. The vesicle composed of bilayer non-ionic surfactants. mostly preferred than liposomes because they stable and cost effective. potentiate pharmacological action molecules by delaying clearance from circulation, protecting biological environment restricting effects only to target cells. In it has applicat...

Magnetism has wide applications in various fields, such as diagnostics, drug targeting, molecular biology, cell isolation, cell purification, hyperthermia, and radioimmunoassay. In this study, we synthesized niosomes doped with iron oxide nanoparticles and a fluorophore for potential applications in magnetically targeted drug delivery. Release kinetics of the fluorophore and cytotoxicity were a...

Innovative niosomes made up of α,ω-hexadecyl-bis-(1-aza-18-crown-6) (bola), Span 80® and cholesterol (2:5:2 molar ratio) are proposed as suitable delivery systems for the administration of 5-fluorouracil (5-FU), an antitumoral compound largely used in the treatment of breast cancer. The bola-niosomes, after sonication procedure, showed mean sizes of ~200 nm and a loading capacity of ~40% with r...