NIP-004 is a novel synthetic compound developed to display human thrombopoietin (TPO) receptor (c-Mpl) agonist activity. NIP-004 displays species specificity, stimulating proliferation or differentiation of human c-Mpl-expressing cells such as UT-7/TPO and human CD34(+) cells but not murine c-Mpl-expressing cells or cynomolgus monkey cells. To test the mechanism of its action, we constructed mu...

LESSONS LEARNED The combination of everolimus and low-dose prednisone administered daily was hypothesized to prevent noninfectious pneumonitis (NIP) and mucositis, two common adverse events related to everolimus. Although mucositis was detected in only one case, all-grade NIP occurred in four of eight cases (50%), and this was considered enough to stop accrual of the study.These data suggest th...

We have measured the production by (C57 x CBA)F(1) mice of hapten-binding antibody in response to a standard dose of 50 microg of alum-precipitated NIP(12)-CG and the influence on this response of the prior administration of hyperimmune antisera raised against the homologous conjugate, the carrier globulin alone, the hapten conjugated to a non-cross-reactive carrier (NIP(4)-OA), or a related ha...

Let T be a consistent o-minimal theory extending the theory of densely ordered groups and let T ′ be a consistent theory. Then there is a complete theory T ∗ extending T such that T is an open core of T ∗, but every model of T ∗ interprets a model of T ′. If T ′ is NIP, T ∗ can be chosen to be NIP as well. From this we deduce the existence of an NIP expansion of the real field that has no dista...

Isolated variable region light chain 315 (VL-315), the VL domain of a myeloma protein of BALB/c origin, induces T cells of BALB/c (H-2d) mice that help the adoptive secondary anti-4-hydroxy-3-iodo-5-nitrophenylacetyl (NIP) antibody response to NIP-Fab315. The location of the epitope recognized by helper cells was examined with two fragments of VL-315, obtained by cleavage with cyanogen bromide ...

Carp (Cyprinus carpio L.) were exposed to nitrofen (NIP) by different routes (via water or food) to compare bioaccumulation parameters and tissue distribution. The bioconcentration factor of NIP was 5,100, and the lipid-corrected biomagnification factor was 0.137. Growth-corrected elimination half lives were 2.1-3.0 days via aqueous exposure and 2.7-2.9 days via dietary exposure. From either up...

In this study, the synthesis and structural properties of a Molecularly Imprinted Polymer (MIP) and a Nonimprinted Polymer (NIP) bearing Fe-porphyrin moiety and amino acid moieties including Histidine (His), Tryptophan (Trp) and Arginine (Arg) are presented. The imprinted and nonimprinted polymeric beads were synthesized by suspension polymerization technique and characterized by using FT-IR sp...

A dinuclear nickel complex with methyl and thiolate ligands, Ni(dadt(Et))Ni(Me)(SDmp) (2), has been synthesized as a dinuclear Ni(d)-Ni(p)-site model of acetyl-CoA synthase (ACS) (dadt(Et) is N,N'-diethyl-3,7-diazanonane-1,9-dithiolate; Dmp is 2,6-dimesitylphenyl). Complex 2 was prepared via 2 methods: (i) ligand substitution of a dinuclear Ni(II)-Ni(II) cation complex [Ni(dadt(Et)) Ni(tmtu)2] ...

Respiratory response to repeated sequences of mild negative inspiratory pressure (NIP) was investigated. Ten healthy male subjects were spontaneously breathing on a Siemens Servo Ventilator. The ventilator delivered the NIP loading (-2 cm H2O during 30 seconds at 1 min interval) and was also used as a measuring device. Six transient response sequences were ensemble-averaged to discern changes i...