Our studies showed that various nitrofuran derivatives have excellent radiosensitizing properties in hypoxic Chinese hamster cells at concentrations at which there is no effect on plating efficiency. The radiosensitizing effect is primarily a dose-modifying effect, with nitrofurantoin, nitrofurazone, and nifuroxime (each at 500 ¿M) in complete medium giving enhancement ratios of 1.65, 2.0, and...

Woody-Karrer, Pearl (Palo Alto Medical Research Foundation, Palo Alto, Calif.) and Joseph Greenberg. Resistance and cross resistance of Escherichia coli S mutants to the radiomimetic agent nitrofurazone. J. Bacteriol. 85:1208-1216. 1963.-Cross-resistance relationships are described for 73 mutants of Escherichia coli strain S selected in one step for resistance to nitrofurazone. The test agents ...

INTRODUCTION The incidence of microbial infections have been increasing day by day in worldwide. Many antibacterial agents are in use against a wide range of infectious diseases1,2. However, the resistance to existing drugs is still a serious problem threat to global public health. This situation leads medicinal chemists to investigate newly synthesized more potent antimicrobial drugs3. Among m...

A reliable, selective and sensitive LC-MS/MS assay has been proposed for the determination of nitrofurantoin in human plasma. The analyte and nitrofurazone were extracted from 100 μL of human plasma via SPE on Strata-X 33 μm extraction cartridges. Chromatography was done on a BDS Hypersil C18 (100 mm × 4.6 mm, 5 μm) column under isocratic conditions. Quantitation was done using the multiple rea...

Engraftment and healing of native or cultured skin grafts depend on adherence, vascularization, and control of microbial contamination in the wound bed. Fibrin sealant is a biocompatible polymer that may be used to promote skin engraftment by serving as a delivery vehicle for antimicrobial drugs. Human fibrin sealant (25 mg/ml) was polymerized with antibacterial agents (mupirocin [32 micrograms...

Three antimicrobial nitroimidazole drugs (metronidazole, dimetridazole, and tinidazole) inhibit a range of clostridia and the protozoan Trichomonas vaginalis ; they have an identical site and mode of action as specific electron acceptors from the pyruvate phosphoroclastic reaction. Analogues of the drugs are compared and the structural requirements for activity explained. The nitrofuran (nitrof...

BACKGROUND Enterococcus faecalis, Escherichia coli, Staphylococcus epidermidis, Pseudomonas aeruginosa and Candida albicans biofilms are major causes of catheter-associated urinary tract infections. Antimicrobial-coated or impregnated urinary catheters are seen as a possible way to prevent these infections. AIMS To determine the biofilm-forming ability of 89 E. faecalis isolates from urinary ...