In a previous paper, an overview of the use of PET/CT in the management of tuberculosis (TB) was provided and the potential role of nitroimidazole imaging in LTBI was considered [1]. During latent TB, dormant bacilli putatively reside in a hypoxic environment of caseating lung granulomas. Exposure of Mycobacterium tuberculosis (Mtb) to progressive hypoxia in vitro induces a dormant state charac...

During January 2008-October 2013, a total of 12 cases of giardiasis at the Chaim Sheba and Shaare Zedek Medical Centers, Israel, did not respond to nitroimidazole; 83.3% were associated with travel and 33% with immunoglobulin deficiency. Among 110 published cases, the most effective treatment was quinacrine (efficacy 90%-100%), but its availability is limited.

starting from 2-(2-pyridyl) imidazole a series of substituted imidazoles (2-5) were prepared. from the reaction of 2-(3-pyridyl) -4-(or 5) nitroimidazole (15) with dimethyl sulfate in alkaline medium 1-methyl-2-(3- pyridy1)-4-nitroimidazole (6,)w as prepared. reaction of compound 15 with diazomethane gave i-methyl-2-(3-pyridy1)-5- nitroimidazol(e7 ) in addition to 6. the antibacterial and antif...

Effect of Combination of Anticancer Agents and Nitroimidazoles on the Survival of Human Hepatocellular Carcinoma Cells under Hypoxic Conditions Sun Ha Lim, M.S., June Yeob Lee, M.D., Ph.D., Sung Hwan Park, M.D., Ph.D., You Hee Kim, M.D., Hun Suk Suh, M.D., Ph.D., Jae Bok Park, M.D., Ph.D., Jongwon Lee, Ph.D. Departments of Biochemistry, Surgery, Laboratory Medicine, Pathology, College of Medici...