A new rapid high yield synthesis of radiolabeled N'-(4-11C-methyl)imipramine has been developed using a reductive-carboxylation approach, in which 11CO2 is reacted with either N'-trimethylsilyldesimipramine or N'-lithium derivative of desimipramine, followed by lithium aluminum hydride reduction, to give no carrier added or carrier added 11C-labeled imipramine respectively. The final product is...

Due to their short-range (2–500 nm), Auger electrons (Auger e−) have the potential induce nano-scale physiochemical damage biomolecules. Although DNA is primary target of e−, it remains challenging maximize interaction between e− and DNA. To assess DNA-damaging effect released as close possible without chemical damage, we radio-synthesized no-carrier-added (n.c.a.) [189, 191Pt]cisplatin evaluat...

A common approach in resolving enantiomers of chiral basic drugs by capillary electrophoresis (CE) is to use cyclodextrins (especially their anionic derivatives) as chiral selector in the acidic buffer (pH ≤ 3) in normal or reversed (carrier) mode. Then, some organic modifiers are added to the buffer solution if the resolution is not satisfactory. In case of cetirizine (CTN), applying the same ...

A common approach in resolving enantiomers of chiral basic drugs by capillary electrophoresis (CE) is to use cyclodextrins (especially their anionic derivatives) as chiral selector in the acidic buffer (pH ≤ 3) in normal or reversed (carrier) mode. Then, some organic modifiers are added to the buffer solution if the resolution is not satisfactory. In case of cetirizine (CTN), applying the same ...

Abstract We developed a novel method for production of no-carrier-added (n.c.a.) [ 188, 189, 191 Pt]Pt II Cl 4 2− from an Ir target material, and then synthesized n.c.a. [*Pt]cis-[Pt 2 (NH 3 ) ] ([*Pt]cisplatin) [*Pt]Pt . was prepared as synthetic precursor *Pt complex by combination resin extraction anion-exchange chromatography after the selective reduction IV 6 with ascorbic acid. The ligand...