Functional magnetic resonance imaging (fMRI) is an emerging methodology which provides various approaches to visualizing regional brain activity non-invasively. Although the exact mechanisms underlying the coupling between neural function and fMRI signal changes remain unclear, fMRI studies have been successful in confirming task-specific activation in a variety of brain regions, providing conv...

One of the most controversial conclusions to emerge from many of the first generation of integrated assessment models (IAMs) of climate policy was the perceived economic optimality of negligible near-term abatement of greenhouse gases. Typically, such studies were conducted using smoothly varying climate change scenarios or impact responses. Abrupt changes observed in the climatic record and do...

RTCA DO-333, Formal Methods Supplement to DO-178C and DO278A, provides guidance for software developers wishing to use formal methods in the certification of airborne systems and air traffic management systems. This paper presents three case studies describing the use of different classes of formal methods to satisfy DO-178C certification objectives. The case studies examine different aspects o...

α5 Subunit-containing GABA(A) receptors (GABA(A)Rs) and α7 neuronal nicotinic-acetylcholine receptors (nAChRs) are members of the Cys-loop family of ligand-gated ion channels (LGICs) that mediate cognitive and attentional processes in the hippocampus. α5 GABA(A)Rs alter network activity by tonic inhibition of CA1/CA3 pyramidal cells of the hippocampus. Postsynaptic α7 nAChRs in the hippocampus ...

(2R,3R,4R)-4-hydroxy-2-(hydroxymethyl)pyrrolidin-3-yl 4-O-(6-deoxyb-D-glucopyranosyl)-a-D-glucopyranoside (CS-1036), which is an a-amylase inhibitor, exhibited biphasic and sustained elimination with a long t1/2 (18.4–30.0 hours) in rats and monkeys, but exhibited a short t1/2 (3.7–7.9 hours) in humans. To clarify the species differences in the t1/2, the plasma protein binding of CS-1036 was ev...

Atmospheric nitrogen dioxide (NO2) can be dry/wet deposited into plant leaves mainly through stomata, with a small fraction of cuticle deposition. Plants in nature present a wide variation in NO2 assimilation and the resistance. The ability of leaf NO2 uptake and efficient remobilization of NO2-derived NO3/NO2 is important for normal plant growth and to withstand nitrogen deprivation. Moreover,...

This paper provides an empirical test of a holistic model of organizational success. It builds upon previous work by Flamholtz (Flamholz, 1995) Managing organizational transitions: implications for corporate and human resource management, European Management Journal 13(1), 39–51.] to develop a model of organizational success and failure. The initial model proposes that there are six key factors...