A malignant melanoma is an abnormal proliferation of pigmented cells in the body. Half these tumors have BRAF mutations, with a worse response to treatment. We present case 58-year-old male nodular lesion on right calf and inguinal lymphadenopathy.

BACKGROUND While representing only 3-4% of malignant skin tumors, cutaneous melanoma is the most aggressive and lethal. Statistical knowledge about the biological behavior of this tumor is essential for guiding daily outpatient practice and aiding public health policies. OBJECTIVES To analyze the profile of patients with cutaneous melanoma attending a pathology department in Teresina (state o...

Nail matrix melanoma, otherwise known as subungual melanoma, is unique in that the actual primary cutaneous melanoma is occult, being covered by the nail plate and the proximal nail fold. Fortunately, the concealed melanoma may produce melanin, which then appears as longitudinal pigmentation in the nail plate. Thus melanin-producing nail matrix melanoma has a distinctive ‘signature’ to the info...

A 41-year-old asymptomatic woman was referred for enucleation of a 7. 5-mm-thick intraocular tumor suspected to be choroidal melanoma. The clinical findings combined with imaging studies suggested instead a diagnosis of giant nodular posterior scleritis. A scleral biopsy was performed to confirm the diagnosis. After 12 years of observation, the lesion has remained stable and visual acuity has b...

CASE REPORT A 30-year-old man was referred to our ocular oncology service with a diagnosis of amelanotic choroidal melanoma of the left eye. The following tests were performed: ophthalmoscopy, fluorescein angiography, indocyanine green angiography, ultrasonography, magnetic resonance imaging and biopsy. DISCUSSION The diagnosis of giant nodular posterior scleritis, as suggested by ultrasonogr...

Tumoral or nodular melanosis in the skin is considered a variation of completely regressed melanoma, presenting clinically as a suspicious pigmented papule or nodule. Microscopically, the lesion consists of a nodular accumulation of heavily pigmented melanophages in the dermis, staining positive for immunohistochemical markers of histiocytic lineage (CD68) and negative for those of melanocytic ...

OBJECTIVE To report the different clinical aspects of malignant melanoma and their varieties in Iraqi patients. METHODS We carried out this study in the Department of Dermatology and Venereology, Baghdad Teaching Hospital, Baghdad, Iraq during the period from 1985-2005. Eighteen patients with malignant melanoma were enrolled in this work. The different clinical aspects and histopathological e...