In this paper we propose a mathematical model to describe the evolution of glioma cells taking into account the viscoelastic properties of brain tissue. The mathematical model is established considering that the glioma cells are of two phenotypes: migratory and proliferative. The evolution of the migratory cells is described by a diffusion-reaction equation of non Fickian type deduced consideri...

Metformin hydrochloride has relatively short plasma half-life, low absolute bioavailability. The need for the administration two to three times a day when larger doses are required can decrease patient compliance. Sustained release formulation that would maintain plasma level for 8-12 h might be sufficient for daily dosing of metformin. Sustained release products are needed for metformin to pro...

The aim of the current investigation is to study the kinetics of drug release pattern from buccal swellable, controlled release tablets of amoxicillin trihydrate. Buccal tablets were prepared with modified gum karaya in 5-20% concentration. Drug release from the formulated amoxicillin trihydrate loaded buccal tablets followed Zero order kinetics resulting in regulated and controlled release for...

2 The work investigates the formulation development, evaluation and optimization of ibuprofen effervescent tablet using 3 factorial designs. The effect of variables viz. xanthan gum and sodium bicarbonate on drug release and hardness of ibuprofen effervescent tablets were analyzed and optimized. The optimized formulation showed the ibuprofen release in sustained manner over a period of 6h. The ...

Degradable, bioceramic bone implants made of calcium polyphosphate (CPP) hold potential for controlled release of therapeutic agents in the treatment of localized bone disease. Magnetic resonance imaging techniques for non-invasively mapping fluid distribution, T(1) and T(2) relaxation times and the apparent diffusion coefficient were performed in conjunction with a drug elution protocol to res...

The aim of this investigation was to develop and optimize bisoprolol fumarate matrix tablets for sustained release application by response surface methodology based on 2(3) factorial design. The effects of the amounts of calcium alginate, HPMC K4M, and Carbopol 943 in bisoprolol fumarate matrix tablets on the properties of bisoprolol fumarate sustained release matrix tablets like drug release a...

The present study was undertaken to develop a suitable transdermal matrix patch of Metoprolol tartrate with different proportions of polyvinyl pyrrolidone (PVP) and chitosan crosslinked with glutaraldehyde (GA). The prepared transdermal patches were subjected to different physicochemical evaluations such as thickness, tensile strength, folding endurance, drug content, swellability, surface pH, ...