Long noncoding RNAs (lncRNAs) play a key role in many important areas of epigenetics, stem cell biology, cancer, signaling and brain function. This emerging class of RNAs constitutes a large fraction of the transcriptome, with thousands of new lncRNAs reported each year. The molecular mechanisms of these RNAs are not well understood. Currently, very little structural data exist. We review the a...

One of the revelations of the post-genomics era has been that that much more of the genome is transcribed than was previously imagined, and that ncRNAs rival protein coding transcripts in genomic abundance. A pre-mRNA splices out much non-coding – though not necessarily nonregulatory – RNA sequence, yet the mature messenger RNA often still retains a significant non-protein-coding RNA sequence t...

association of satellite rna with cucumber mosaic virus (cmv) leads to either attenuation or enhancement of the viral symptoms. for detection of the satellite rnas in iranian isolates of cmv, plant samples showing viral symptoms were collected from different farms in the provinces of east- and west- azerbayjan and ardebil. these samples were inoculated onto the experimental host plants in green...

Protein–RNA interactions are at the heart of cell regulation. From transcription, processing, storage, and translation, all the stages in the life cycle of an RNA depend on interactions with proteins. Although technologies are making remarkable progress in unraveling the landscape of protein–RNA interactions, many key issues are unclear.We still have to identify howmany proteins have RNA-bindin...

Background: Non-coding RNAs apply regulations on expression or function of a gene. A class of non-coding RNAs, natural antisense transcripts, might overlap with their flanking genes and emerge a new complexity upon regulation. WRAP53, is a natural antisense transcript overlapped in a head-to-head manner on the opposite strand of TP53. It has 3 transcripts of which WRAP53β produ...