BACKGROUND Hypertension drives the global burden of cardiovascular disease and its prevalence is estimated to increase by 30% by the year 2025. Nonadherence to chronic medication regimens is common; approximately 43% to 65.5% of patients who fail to adhere to prescribed regimens are hypertensive patients. Nonadherence to medications is a potential contributing factor to the occurrence of concom...

BACKGROUND Nonadherence to statins limits the benefits of this common drug class. Individual studies assessing predictors of nonadherence have produced inconsistent results. OBJECTIVE To identify reliable predictors of nonadherence to statins through systematic review and meta-analysis. METHODS Multiple databases, including MEDLINE, EMBASE, and PsycINFO, were searched (from inception throug...

Background: The effectiveness of value-based insurance design is based on nonadherence, which derives solely from patients’ economic constraints. Objective: Our objective was to examine the extent of cost-related nonadherence to chronic medications and to analyze its potential determinants. Methods: We conducted a telephone survey among a representative sample of Maccabi Healthcare Services chr...

Objectives The epilepsy treatment gap is large in low- and middle-income countries, but the reasons behind nonadherence to treatment with antiepileptic drugs (AEDs) across African countries remain unclear. We investigated the extent to which AEDs are not taken and associated factors in people with active convulsive epilepsy (ACE) identified in cross-sectional studies conducted in five African c...

OBJECTIVE The aim of this study was to examine the complex relationships among neurocognition, insight and nonadherence in patients with schizophrenia. METHODS DESIGN Cross-sectional study. INCLUSION CRITERIA Diagnosis of schizophrenia according to the DSM-IV-TR criteria. DATA COLLECTION Neurocognition was assessed using a global approach that addressed memory, attention, and executive...

BACKGROUND Nonadherence to antiretroviral therapy (ARVT) is an important behavioral determinant of the success of ARVT. Nonadherence may lead to virological failure, and increases the risk of development of drug resistance. Understanding the prevalence of nonadherence and associated factors is important to inform secondary HIV prevention efforts. METHODOLOGY/PRINCIPAL FINDINGS We used data fr...

OBJECTIVE Examine treatment adherence rates in pediatric eosinophilic gastrointestinal disorders (EGID). METHODS Participants were children aged 2.5-18 years with eosinophilic esophagitis or eosinophilic gastroenteritis (EGE) and their caregivers. A multimethod, multi-informant assessment including parent report and electronic monitoring was utilized, with a 90% cut point for nonadherence. ...

This review aimed to ascertain the extent to which nonadherence to treatment protocol is reported and addressed in a cohort of published analyses of randomised controlled trials (RCTs). One hundred publications of RCTs, randomly selected from those published in BMJ, New England Journal of Medicine, the Journal of the American Medical Association and The Lancet during 2008, were reviewed to dete...

BACKGROUND Little is known about the effect of social support on nonadherence in persons with schizophrenia, especially in developing Asian countries where social support is considered to be imperative. Additionally, the role of depression as a mediator in the association between social support deficits and nonadherence has not been evaluated. METHODS This was a cross-sectional study conducte...

OBJECTIVE Poor adherence to complex multimodal therapies is a widely recognized problem in the daily care of dialysis patients, contributing to excess morbidity and mortality of this population. While a few studies have been devoted to understanding patient nonadherence, their results were somewhat controversial. The goals of this review are to quantify nonadherence to certain oral medications,...