The influence of several nootropic drugs (piracetam, pyritinol, meclofenoxat, methylglucamine orotate (MGO) and dihydroergotoxine (DHET) on both the ethanol preference and the enhanced seizure susceptibility after a single dose of ethanol was studied. Piracetam, MGO and DHET reduce the ethanol drinking in ethanol-preferring mice. The enhanced seizure susceptibility after a single dose of ethano...

BACKGROUND The aerial parts of Vitis vinifera (common grape or European grape) have been widely used in Ayurveda to treat a variety of common and stress related disorders. In the present investigation, the seed extract of V. vinifera was evaluated for antistress activity in normal and stress induced rats. Furthermore, the extract was studied for nootropic activity in rats and in-vitro antioxida...

Gold, P. E. (1986) Behav. Neural Biol. 46,87-98 Jensen, L. H., Petersen, E. N., Braestrup, C., Honore, T., Kehr, W., Stephens, D. N., Seidelmann, D. & Schmiechen, R. (1984) I-’sycliopharmricologyo~ 83,2492 5 6 Jensen, L. H., Stephens, D. N., Sarter, M. & Petersen, E. N. ( 1 987) Bruin. Res. Bull. 19, 359-364 Petkow, V., Georgier, V., Getova, D. & Petkov, V. (1983) Acfu I’hysiol. I’harmacol. Bul...

The structure of the title compound, C(14)H(28)N(3)O(2) (+)·HSO(4) (-), a nootropic drug (pramiracetam) investigated for cognition-enhancing properties, is closely similar to that of the previously determined acetonitrile solvate, both structures being characterized by the presence of ribbons of hydrogen-bonded ions. The pyrrolidine ring adopts an envelope conformation.

The present study was carried out to evaluate CNS activity of ethanolic extract of roots of Anacyclus pyrethrum that includes general behavior studies, sedative, muscle relaxant, anxiolytic, nootropic activity and antidepressant studies in rats. The results reveal potential neuropharmacological activity of Anacyclus pyrethrum as nootropic and also having antidepressant property. Further neuroch...