نتایج جستجو برای: notch software
تعداد نتایج: 455693 فیلتر نتایج به سال:
The Notch signaling pathway governs many distinct cellular processes by regulating transcriptional programs. The transcriptional response initiated by Notch is highly cell context dependent, indicating that multiple factors influence Notch target gene selection and activity. However, the mechanism by which Notch drives target gene transcription is not well understood. Herein, we identify and ch...
Ultra Wideband (UWB) is a new emerging and promising technology as it can accommodate higher data over a large bandwidth. we proposed a Printed Square-shape UWB Antenna With Dual Band-Notched Characteristics. A simple square patch antenna has been fed through a 50 Ω microstrip feedline .A rectangular notch has been etched on the ground plane to reject the interference of WIMAX Band (3GHZ-4.7GHZ...
This study investigated the roles of Notch‑1 in colorectal carcinoma, to assess the mechanisms. The expression of Notch‑1 and its ligand-Jagged1 was detected in human colorectal carcinoma, colorectal adenoma, paracancerous tissue and normal colorectal tissue by immunohistochemistry. Colorectal carcinoma cell lines were utilized to confirm the expression of Notch‑1 in colorectal carcinoma cells....
Notch signal transduction is mediated by proteolysis of the receptor and translocation of the intracellular domain (IC) into the nucleus, where it functions as a regulator of HES gene expression after binding to the DNA-binding protein RBP-J kappa. The mammalian Notch receptors are structurally very similar, but have distinct functions. Most notably, Notch 1 IC is a potent activator of the HES ...
The article analyzes a prestressed reinforced concrete dapped-end beam of rectangular cross-section. negative effect reinforcement prestressing on the bearing capacity is analyzed. numerical model made based an experiment and nonlinear analysis performed using DIANA FEA software package to determine different intensity beam. results are compared with analytical calculations behavior described i...
Genetic and phenotypic analysis of strawberry notch suggests that its gene product is required during embryogenesis and oogenesis, and for the development of the eye, wing and leg. Several lines of evidence suggest that strawberry notch participates together with Notch in many common pathways. A number of strawberry notch mutant phenotypes are similar to those of Notch mutants and can be rescue...
Notch receptor regulates differentiation of almost all tissues and organs during animal development. Many mechanisms function at the protein level to finely regulate Notch activity. Here we provide evidence for Notch regulation at an earlier step - mRNA 3' processing. Processing at the Notch consensus polyadenylation site appears by default to be suppressed in Drosophila embryos. Interference w...
BACKGROUND Lung cancers are resistant to conventional chemotherapeutic interventions such as paclitaxel. Notch signaling is crucial in the chemoresistance of lung cancer cells. The Notch inhibitor gamma-secretase inhibitor (GSI) inhibits the Notch signaling pathway. MATERIAL AND METHODS Here, we evaluated how Notch-3 inhibition by GSI can enhance the sensitivity of lung cancer cells to paclitax...
sudden fracture is one of the major failure modes in brittle materials. plexiglass (polymethyl methacrylate) is a well known brittle polymer, widely used in various industries. many types of notches, particularly v-shaped notches, are sometimes used in the components made of plexiglass. these notches can dramatically decrease the load bearing capacity of components due to the concentration of s...
High expression of Notch-1 and Jagged-1 mRNA correlates with poor prognosis in breast cancer. Elucidating the cross-talk between Notch and other major breast cancer pathways is necessary to determine which patients may benefit from Notch inhibitors, which agents should be combined with them, and which biomarkers indicate Notch activity in vivo. We explored expression of Notch receptors and liga...
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