BACKGROUND Notch receptors normally play a key role in guiding a variety of cell fate decisions during development and differentiation of metazoan organisms. On the other hand, dysregulation of Notch1 signaling is associated with many different types of cancer as well as tumor angiogenesis, making Notch1 a potential therapeutic target. PRINCIPAL FINDINGS Here we report the in vitro activities...

OBJECTIVES Reduction of breathing variability is associated with adverse outcome. During mechanical ventilation, the variability of ventilatory pressure is dependent on the ventilatory mode. During neurally adjusted ventilatory assist (NAVA), the support is proportional to electrical activity of the diaphragm (EAdi), which reflects the respiratory center output. The variability of EAdi is, ther...

Background sperm selection is generally used to describe methods for separation of spermatozoa for in-vitro-assisted reproduction. Few studies reported relation in vivo fertility and semen parameters after selection of fertile spermatozoa; hence, our research attempt to assess different semen parameters after post-thaw (PT) or after selecting sperm sample (SSp), using density gradient separatio...

In a memorandum dated November 25, 1997, NRR requested RES to perform appropriate research and provide independent confirmation of the applicability of Arrhenius methodology to meet the environmental qualification (EQ) requirements for LOCA and post-LOCA environments. RES was requested to support the NRR reviews of licensees' requests for (1) power uprate amendments, (2) reevaluation of qualifi...

Higher Notch signaling is known to be associated with hematological and solid cancers. We developed a potential immunotherapeutic monoclonal antibody (MAb) specific for the Negative Regulatory Region of Notch1 (NRR). The MAb604.107 exhibited higher affinity for the "Gain-of-function" mutants of Notch1 NRR associated with T Acute lymphoblastic Leukemia (T-ALL). Modeling of the mutant NRR with 12...

The use of lysosomal stability in the mussel, Mytilus galloprovincialis, as a potential biomarker of environmental contamination has been evaluated along the Portuguese coast. To this end, the neutral red retention (NRR) time was measured in mussel haemocytes gathered from nine different locations reflecting different degrees of anthropogenic contamination. Mussels collected in the vicinity of ...

background: noise-induced hearing loss (nihl) is one of the most common occupational diseases and the second most common cause of workers' claims for occupational injuries. objective: due to high prevalence of nihl and several reports of improper use of hearing protective devices (hpds), we conducted this study to compare the effect of face-to-face training in effective use of earplugs with app...

Fast neutron resonance radiography (NRR) has been devised as an elemental imaging method with applications such as contraband detection and mineral analysis. In NRR, a two-dimensional (2-D) elemental mapping of hydrogen, carbon, nitrogen, oxygen, and the sum of other elements is obtained from fast neutron radiographic images, taken at different neutron energies and chosen to cover the resonance...