The heterogeneous interface for the mobile node is the key feature for the next generation mobile world. It provides the flexibility for the mobile devices for moving devices to the next available best network for high data rate connection. So it is firstly important to develop in ns2 for the research and educational purposes. It is very important to develop it in ns2 so that we can do experime...

The family Flaviviridae contains three genera of positive-strand RNA viruses, namely, Flavivirus, Hepacivirus (e.g., hepatitis C virus [HCV]), and Pestivirus. Pestiviruses, like bovine viral diarrhea virus (BVDV), bear a striking degree of similarity to HCV concerning polyprotein organization, processing, and function. Along this line, in both systems, release of nonstructural protein 3 (NS3) i...

Viruses of the Paramyxoviridae family, such as the respiratory syncytial virus (RSV), suppress cellular innate immunity represented by type I interferon (IFN) for optimal growth in their hosts. The two unique nonstructural (NS) proteins, NS1 and NS2, of RSV suppress IFN synthesis, as well as IFN function, but their exact targets are still uncharacterized. Here, we investigate if either or both ...

This paper proposed the design model and implementing method of virtual Computer Networks lab which is based on NS2. In this lab, the client part is implemented with Java Applet, NS2 is used as computing platform, Nam is used as the tool for displaying in the client, and Java RMI is used for communication between the server and the client. The virtual experiment equipments are implemented with ...

Molecular covariation of highly polymorphic viruses is thought to have crucial effects on viral replication and fitness. This study employs association rule data mining of hepatitis C virus (HCV) sequences to search for specific evolutionary covariation and then tests functional relevance on HCV replication. Data mining is performed between nucleotides in the untranslated regions 5' and 3'UTR, ...

Processing at the C terminus of the NS2 protein of hepatitis C virus (HCV) is mediated by a virus-encoded protease which spans most of the NS2 protein and part of the NS3 polypeptide. In vitro cotranslational cleavage at the 2-3 junction is stimulated by the presence of microsomal membranes and ultimately results in the membrane insertion of the NS2 polypeptide. To characterize the biochemical ...

NS2 is a discrete event simulator targeted at networking research. NS2 provides substantial support for simulation of routing protocols over wired and wireless (local and satellite) networks. NS2 uses TCL script for its front end and C++ as its back end [1,5]. NS2 is completely command based and one needs to create a TCL file for running any network simulation. Therefore, it’s very tedious for ...

The abundant R2 mRNA encoded by the single left-end promoter of Aleutian mink disease parvovirus is tricistronic; it not only expresses the capsid proteins VP1 and VP2 but is also the major source for the nonstructural protein NS2. A cis-acting sequence within the NS2 gene was shown to be required for efficient capsid protein production, and its effect displayed a distinct location dependence. ...

Chronic hepatitis C virus (HCV) infection is an important cause of morbidity and mortality globally, and often leads to end-stage liver disease. The DNA damage checkpoint pathway induces cell cycle arrest for repairing DNA in response to DNA damage. HCV infection has been involved in this pathway. In this study, we assess the effects of HCV NS2 on DNA damage checkpoint pathway. We have observed...