The growth of mammary carcinoma induced by oral 3-methylcholanthrene in female Wistar rats is retarded by ovariectomy and by food restriction sufficient to produce 12-14% body weight loss. Estradici benzoate (NSC 9566), 5-fluorouracil (NSC 19893), miracil D (NSC 14574), mitomycin C (NSC 26980), and AB-100 (NSC 37095) showed inhibitory activity. The best tumor inhibition without mortality was el...

BACKGROUND The use of conjugated polymers allows versatile interactions between cells and flexible processable materials, while providing a platform for electrical stimulation, which is particularly relevant when targeting differentiation of neural stem cells and further application for therapy or drug screening. METHODS Materials were tested for cytotoxicity following the ISO10993-5. PEDOT...

Proinflammatory factors from activated T cells inhibit neurogenesis in adult animal brain and cultured human fetal neural stem cells (NSC). However, the role of inhibition of neurogenesis in human neuroinflammatory diseases is still uncertain because of the difficulty in obtaining adult NSC from patients. Recent developments in cell reprogramming suggest that NSC may be derived directly from ad...

Transport of 5-(dimethyltriazeno)imidazole4-carboxamide (NSC 45388) and the 3,3-bis(2-chloroethyl) derivative (NSC 82196) was studied in vitro in Ll210 cells and in drug-resistant sublines. Uptake of both compounds was temperature sensitive and apparently nonsaturable. Accumulated NSC 45388 could be removed from the cells by brief suspension in buffer at 37°.In contrast, accumulated NSC 82 196...

Remobilisation of non-structural carbohydrates (NSC) from leaves and stems and unloading into developing grains are essential for yield formation of rice. In present study, three recombinant inbred lines of rice, R91, R156 and R201 have been tested for source-flow-sink related attributes determining the nature of NSC accumulation and translocation at two nitrogen levels in the field. Compared t...

NSC 314622 was found to have a cytotoxicity profile comparable to the topoisomerase I (top1) inhibitors camptothecin (CPT) and saintopin in the National Cancer Institute In Vitro Anticancer Drug Discovery Screen using the COMPARE analysis. In vitro data showed that NSC 314622 induced DNA cleavage in the presence of top1 at micromolar concentrations. Cleavage specificity was different from CPT i...

Nuclear star clusters (NSCs) are massive found ubiquitously in the centres of galaxies, from dwarf regime to ellipticals and spirals. The fraction nucleated galaxies is as high $>$ 90 % at $M_{\text{gal}} \sim 10^9 M_\odot$. However, how NSC formation mechanisms work different regimes what determines galaxy nucleation still unclear. dissipationless accretion infalling globular (GCs) situ stars ...

The motor neuron-like cell line NSC-34 has become a widely used in vitro model for motor neuron biology and pathology. We established a tetracycline-regulated gene expression system in this cell line by stably transfecting pTet-Off, which codifies for the tetracycline transactivator, the regulatory protein tTA. The monoclonal cell lines (NSC-34-tTA) were evaluated for the presence of functional...

Nearest shrunken centroids (NSC) is a popular classification method for microarray data. NSC calculates centroids for each class and "shrinks" the centroids toward 0 using soft thresholding. Future observations are then assigned to the class with the minimum distance between the observation and the (shrunken) centroid. Under certain conditions the soft shrinkage used by NSC is equivalent to a L...

Neural stem/progenitor cells (NSC) have the potential for treatment of a wide range of neurological diseases such as Parkinson Disease and multiple sclerosis. Currently, NSC have been isolated only from hippocampus and subventricular zone (SVZ) of the adult brain. It is not known whether NSC can be found in all parts of the developing mid-trimester central nervous system (CNS) when the brain un...