نتایج جستجو برای: nuclear abnormalities
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A total of 15 morphological abnormalities characteristic of dyserythropoiesis were evaluated in bone marrow smears stained with May-Grunwald-Giemsa stain. Abnormalities were classified as: (a) anomalies of the nucleus (binuclearity, multinuclearity, nuclear lobulation, budding, fragmentation, chromatin lumping and pyknosis, intranuclear bridging, extrusion of the nucleus); and (b) anomalies of ...
Hutchinson-Gilford progeria syndrome (HGPS), a fatal premature aging disease, is caused by a single-nucleotide mutation in the LMNA gene. Previous reports have focused on nuclear phenotypes in HGPS cells, yet the potential contribution of the mitochondria, a key player in normal aging, remains unclear. Using high-resolution microscopy analysis, we demonstrated a significantly increased fraction...
In various animal species, the main cause of pregnancy loss in conceptuses obtained by somatic cell nuclear transfer (SCNT) are placental abnormalities. Most abnormalities described in SCNT pregnancies (such as placentomegaly, reduced vascularisation, hypoplasia of trophoblastic epithelium) suggest that placental cell degeneration may be triggered by mitochondrial failure. We hypothesized that ...
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